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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Int+Med+Res 1986 ; 14 (4): 188-92 Nephropedia Template TP
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Comparison of the diuretic effects of single dose frusemide/triamterene and hydrochlorothiazide/amiloride in healthy adults #MMPMID3758469
Kohvakka A; Hussi E
J Int Med Res 1986[]; 14 (4): 188-92 PMID3758469show ga
The diuretic and potassium- and magnesium-conserving action of a single dose of frusemide/triamterene, F + TRI (40 mg/50 mg), and hydrochlorothiazide/amiloride, HCT + AMI (50 mg/5 mg), fixed combination preparations were compared in ten healthy adults in a randomised double-blind placebo-controlled study. Urinary volume during 24 hours was significantly higher after HCT + AMI ingestion than after F + TRI. The urine and sodium excretions caused by HCT + AMI lasted markedly longer and were smoother than the short and somewhat unpleasant effects of F + TRI. HCT + AMI also spared potassium and magnesium relatively more effectively than F + TRI.