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10.1016/j.isci.2023.107236 http://scihub22266oqcxt.onion/10.1016/j.isci.2023.107236 37496680!10366500!37496680     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=37496680&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       iScience 2023 ; 26 (7): 107236 Nephropedia Template TP {{tp|p=37496680|t=2023. Human neutrophils communicate remotely via calcium-dependent glutamate-induced glutamate release |pdf=|usr=}}{{37496680}} gab.com Text Human neutrophils communicate remotely via calcium-dependent glutamate-induced glutamate release JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=37496680 #FOAvip Neutrophils are white blood cells that are critical to acute inflammatory and adaptive immune responses. Their swarming-pattern behavior is controlled by multiple cellular cascades involving calcium-dependent release of various signaling molecules. Previous studies have reported that neutrophils express glutamate receptors and can release glutamate but evidence of direct neutrophil-neutrophil communication has been elusive. Here, we hold semi-suspended cultured human neutrophils in patch-clamp whole-cell mode to find that calcium mobilization induced by stimulating one neutrophil can trigger an N-methyl-D-aspartate (NMDA) receptor-driven membrane current and calcium signal in neighboring neutrophils. We employ an enzymatic-based imaging assay to image, in real time, glutamate release from neutrophils induced by glutamate released from their neighbors. These observations provide direct evidence for a positive-feedback inter-neutrophil communication that could contribute to mechanisms regulating communal neutrophil behavior. Twit Text FOAVip Human neutrophils communicate remotely via calcium-dependent glutamate-induced glutamate release ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=37496680 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=37496680 #FOAvip English Wikipedia <ref>{{Cite pmid|37496680}}</ref> Human neutrophils communicate remotely via calcium-dependent glutamate-induced glutamate release #MMPMID37496680 Kopach O; Sylantyev S; Bard L; Michaluk P; Heller JP; Gutierrez Del Arroyo A; Ackland GL; Gourine AV; Rusakov DA iScience 2023[Jul]; 26 (7): 107236 PMID37496680show ga Neutrophils are white blood cells that are critical to acute inflammatory and adaptive immune responses. Their swarming-pattern behavior is controlled by multiple cellular cascades involving calcium-dependent release of various signaling molecules. Previous studies have reported that neutrophils express glutamate receptors and can release glutamate but evidence of direct neutrophil-neutrophil communication has been elusive. Here, we hold semi-suspended cultured human neutrophils in patch-clamp whole-cell mode to find that calcium mobilization induced by stimulating one neutrophil can trigger an N-methyl-D-aspartate (NMDA) receptor-driven membrane current and calcium signal in neighboring neutrophils. We employ an enzymatic-based imaging assay to image, in real time, glutamate release from neutrophils induced by glutamate released from their neighbors. These observations provide direct evidence for a positive-feedback inter-neutrophil communication that could contribute to mechanisms regulating communal neutrophil behavior. ?Human neutrophils communicate remotely via calcium-dependent glutamate(epmc).pdf DeepDyve Pubget Overpricing