Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.7554/eLife.86129 http://scihub22266oqcxt.onion/10.7554/eLife.86129 37449820!10348743!37449820     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=37449820&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Elife 2023 ; 12 (?): ? Nephropedia Template TP {{tp|p=37449820|t=2023. Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15 |pdf=|usr=}}{{37449820}} gab.com Text Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15 JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=37449820 #FOAvip Cystathionine-beta-synthase (CBS)-pair domain divalent metal cation transport mediators (CNNMs) are an evolutionarily conserved family of magnesium transporters. They promote efflux of Mg(2+) ions on their own and influx of divalent cations when expressed with the transient receptor potential ion channel subfamily M member 7 (TRPM7). Recently, ADP-ribosylation factor-like GTPase 15 (ARL15) has been identified as CNNM-binding partner and an inhibitor of divalent cation influx by TRPM7. Here, we characterize ARL15 as a GTP and CNNM-binding protein and demonstrate that ARL15 also inhibits CNNM2 Mg(2+) efflux. The crystal structure of a complex between ARL15 and CNNM2 CBS-pair domain reveals the molecular basis for binding and allowed the identification of mutations that specifically block binding. A binding deficient ARL15 mutant, R95A, failed to inhibit CNNM and TRPM7 transport of Mg(2+) and Zn(2+) ions. Structural analysis and binding experiments with phosphatase of regenerating liver 2 (PRL2 or PTP4A2) showed that ARL15 and PRLs compete for binding CNNM to coordinate regulation of ion transport by CNNM and TRPM7. Twit Text FOAVip Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15 ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=37449820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=37449820 #FOAvip English Wikipedia <ref>{{Cite pmid|37449820}}</ref> Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15 #MMPMID37449820 Mahbub L; Kozlov G; Zong P; Lee EL; Tetteh S; Nethramangalath T; Knorn C; Jiang J; Shahsavan A; Yue L; Runnels L; Gehring K Elife 2023[Jul]; 12 (?): ? PMID37449820show ga Cystathionine-beta-synthase (CBS)-pair domain divalent metal cation transport mediators (CNNMs) are an evolutionarily conserved family of magnesium transporters. They promote efflux of Mg(2+) ions on their own and influx of divalent cations when expressed with the transient receptor potential ion channel subfamily M member 7 (TRPM7). Recently, ADP-ribosylation factor-like GTPase 15 (ARL15) has been identified as CNNM-binding partner and an inhibitor of divalent cation influx by TRPM7. Here, we characterize ARL15 as a GTP and CNNM-binding protein and demonstrate that ARL15 also inhibits CNNM2 Mg(2+) efflux. The crystal structure of a complex between ARL15 and CNNM2 CBS-pair domain reveals the molecular basis for binding and allowed the identification of mutations that specifically block binding. A binding deficient ARL15 mutant, R95A, failed to inhibit CNNM and TRPM7 transport of Mg(2+) and Zn(2+) ions. Structural analysis and binding experiments with phosphatase of regenerating liver 2 (PRL2 or PTP4A2) showed that ARL15 and PRLs compete for binding CNNM to coordinate regulation of ion transport by CNNM and TRPM7. |*Monomeric GTP-Binding Proteins[MESH] |*TRPM Cation Channels/genetics[MESH] |Biological Transport[MESH] |Cations, Divalent[MESH]Structural insights into regulation of CNNM-TRPM7 divalent cation upta(epmc).pdf DeepDyve Pubget Overpricing