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10.1002/brb3.3136 http://scihub22266oqcxt.onion/10.1002/brb3.3136 37366640!10498085!37366640     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=37366640&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Brain+Behav 2023 ; 13 (9): e3136 Nephropedia Template TP {{tp|p=37366640|t=2023. Mechanical properties of the brain: Focus on the essential role of Piezo1-mediated mechanotransduction in the CNS |pdf=|usr=}}{{37366640}} gab.com Text Mechanical properties of the brain: Focus on the essential role of Piezo1-mediated mechanotransduction in the CNS JO: Brain Behav http://www.kidney.de/pget.php?&tw=1&pmid=37366640 #FOAvip BACKGROUND: The brain is a highly mechanosensitive organ, and changes in the mechanical properties of brain tissue influence many physiological and pathological processes. Piezo type mechanosensitive ion channel component 1 (Piezo1), a protein found in metazoans, is highly expressed in the brain and involved in sensing changes of the mechanical microenvironment. Numerous studies have shown that Piezo1-mediated mechanotransduction is closely related to glial cell activation and neuronal function. However, the precise role of Piezo1 in the brain requires further elucidation. OBJECTIVE: This review first discusses the roles of Piezo1-mediated mechanotransduction in regulating the functions of a variety of brain cells, and then briefly assesses the impact of Piezo1-mediated mechanotransduction on the progression of brain dysfunctional disorders. CONCLUSIONS: Mechanical signaling contributes significantly to brain function. Piezo1-mediated mechanotransduction regulates processes such as neuronal differentiation, cell migration, axon guidance, neural regeneration, and oligodendrocyte axon myelination. Additionally, Piezo1-mediated mechanotransduction plays significant roles in normal aging and brain injury, as well as the development of various brain diseases, including demyelinating diseases, Alzheimer's disease, and brain tumors. Investigating the pathophysiological mechanisms through which Piezo1-mediated mechanotransduction affects brain function will give us a novel entry point for the diagnosis and treatment of numerous brain diseases. Twit Text FOAVip Mechanical properties of the brain: Focus on the essential role of Piezo1-mediated mechanotransduction in the CNS ????Brain Behav http://www.kidney.de/pget.php?&tw=1&pmid=37366640 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=37366640 #FOAvip English Wikipedia <ref>{{Cite pmid|37366640}}</ref> Mechanical properties of the brain: Focus on the essential role of Piezo1-mediated mechanotransduction in the CNS #MMPMID37366640 Zheng Q; Liu H; Yu W; Dong Y; Zhou L; Deng W; Hua F Brain Behav 2023[Sep]; 13 (9): e3136 PMID37366640show ga BACKGROUND: The brain is a highly mechanosensitive organ, and changes in the mechanical properties of brain tissue influence many physiological and pathological processes. Piezo type mechanosensitive ion channel component 1 (Piezo1), a protein found in metazoans, is highly expressed in the brain and involved in sensing changes of the mechanical microenvironment. Numerous studies have shown that Piezo1-mediated mechanotransduction is closely related to glial cell activation and neuronal function. However, the precise role of Piezo1 in the brain requires further elucidation. OBJECTIVE: This review first discusses the roles of Piezo1-mediated mechanotransduction in regulating the functions of a variety of brain cells, and then briefly assesses the impact of Piezo1-mediated mechanotransduction on the progression of brain dysfunctional disorders. CONCLUSIONS: Mechanical signaling contributes significantly to brain function. Piezo1-mediated mechanotransduction regulates processes such as neuronal differentiation, cell migration, axon guidance, neural regeneration, and oligodendrocyte axon myelination. Additionally, Piezo1-mediated mechanotransduction plays significant roles in normal aging and brain injury, as well as the development of various brain diseases, including demyelinating diseases, Alzheimer's disease, and brain tumors. Investigating the pathophysiological mechanisms through which Piezo1-mediated mechanotransduction affects brain function will give us a novel entry point for the diagnosis and treatment of numerous brain diseases. |*Brain/metabolism[MESH] |*Mechanotransduction, Cellular[MESH] |Axons[MESH] |Brain Neoplasms[MESH] |Humans[MESH] |Neurons[MESH]Mechanical properties of the brain: Focus on the essential role of Pi(epmc).pdf DeepDyve Pubget Overpricing