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10.3389/fimmu.2023.1184000 http://scihub22266oqcxt.onion/10.3389/fimmu.2023.1184000 37207232!10189129!37207232     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=37207232&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Front+Immunol 2023 ; 14 (?): 1184000 Nephropedia Template TP {{tp|p=37207232|t=2023. Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling |pdf=|usr=}}{{37207232}} gab.com Text Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=37207232 #FOAvip Sensory neurons cooperate with barrier tissues and resident immune cells to form a significant aspect of defensive strategies in concert with the immune system. This assembly of neuroimmune cellular units is exemplified across evolution from early metazoans to mammalian life. As such, sensory neurons possess the capability to detect pathogenic infiltrates at barrier surfaces. This capacity relies on mechanisms that unleash specific cell signaling, trafficking and defensive reflexes. These pathways exploit mechanisms to amplify and enhance the alerting response should pathogenic infiltration seep into other tissue compartments and/or systemic circulation. Here we explore two hypotheses: 1) that sensory neurons' potential cellular signaling pathways require the interaction of pathogen recognition receptors and ion channels specific to sensory neurons and; 2) mechanisms which amplify these sensing pathways require activation of multiple sensory neuron sites. Where possible, we provide references to other apt reviews which provide the reader more detail on specific aspects of the perspectives provided here. Twit Text FOAVip Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=37207232 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=37207232 #FOAvip English Wikipedia <ref>{{Cite pmid|37207232}}</ref> Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling #MMPMID37207232 Millet A; Jendzjowsky N Front Immunol 2023[]; 14 (?): 1184000 PMID37207232show ga Sensory neurons cooperate with barrier tissues and resident immune cells to form a significant aspect of defensive strategies in concert with the immune system. This assembly of neuroimmune cellular units is exemplified across evolution from early metazoans to mammalian life. As such, sensory neurons possess the capability to detect pathogenic infiltrates at barrier surfaces. This capacity relies on mechanisms that unleash specific cell signaling, trafficking and defensive reflexes. These pathways exploit mechanisms to amplify and enhance the alerting response should pathogenic infiltration seep into other tissue compartments and/or systemic circulation. Here we explore two hypotheses: 1) that sensory neurons' potential cellular signaling pathways require the interaction of pathogen recognition receptors and ion channels specific to sensory neurons and; 2) mechanisms which amplify these sensing pathways require activation of multiple sensory neuron sites. Where possible, we provide references to other apt reviews which provide the reader more detail on specific aspects of the perspectives provided here. |*Ganglia, Spinal/metabolism[MESH] |*Sensory Receptor Cells/metabolism[MESH] |Animals[MESH] |Immune System[MESH] |Mammals[MESH]Pathogen recognition by sensory neurons: hypotheses on the specificity(epmc).pdf DeepDyve Pubget Overpricing