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10.1038/s41467-023-38362-3 http://scihub22266oqcxt.onion/10.1038/s41467-023-38362-3 37156763!10167348!37156763     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=37156763&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Nat+Commun 2023 ; 14 (1): 2639 Nephropedia Template TP {{tp|p=37156763|t=2023. Structural mechanisms of TRPM7 activation and inhibition |pdf=|usr=}}{{37156763}} gab.com Text Structural mechanisms of TRPM7 activation and inhibition JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=37156763 #FOAvip The transient receptor potential channel TRPM7 is a master regulator of the organismal balance of divalent cations that plays an essential role in embryonic development, immune responses, cell mobility, proliferation, and differentiation. TRPM7 is implicated in neuronal and cardiovascular disorders, tumor progression and has emerged as a new drug target. Here we use cryo-EM, functional analysis, and molecular dynamics simulations to uncover two distinct structural mechanisms of TRPM7 activation by a gain-of-function mutation and by the agonist naltriben, which show different conformational dynamics and domain involvement. We identify a binding site for highly potent and selective inhibitors and show that they act by stabilizing the TRPM7 closed state. The discovered structural mechanisms provide foundations for understanding the molecular basis of TRPM7 channelopathies and drug development. Twit Text FOAVip Structural mechanisms of TRPM7 activation and inhibition ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=37156763 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=37156763 #FOAvip English Wikipedia <ref>{{Cite pmid|37156763}}</ref> Structural mechanisms of TRPM7 activation and inhibition #MMPMID37156763 Nadezhdin KD; Correia L; Narangoda C; Patel DS; Neuberger A; Gudermann T; Kurnikova MG; Chubanov V; Sobolevsky AI Nat Commun 2023[May]; 14 (1): 2639 PMID37156763show ga The transient receptor potential channel TRPM7 is a master regulator of the organismal balance of divalent cations that plays an essential role in embryonic development, immune responses, cell mobility, proliferation, and differentiation. TRPM7 is implicated in neuronal and cardiovascular disorders, tumor progression and has emerged as a new drug target. Here we use cryo-EM, functional analysis, and molecular dynamics simulations to uncover two distinct structural mechanisms of TRPM7 activation by a gain-of-function mutation and by the agonist naltriben, which show different conformational dynamics and domain involvement. We identify a binding site for highly potent and selective inhibitors and show that they act by stabilizing the TRPM7 closed state. The discovered structural mechanisms provide foundations for understanding the molecular basis of TRPM7 channelopathies and drug development. |*TRPM Cation Channels/metabolism[MESH]Structural mechanisms of TRPM7 activation and inhibition (epmc).pdf DeepDyve Pubget Overpricing