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10.3390/nu15081930 http://scihub22266oqcxt.onion/10.3390/nu15081930 37111149!10146686!37111149     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=37111149&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Nutrients 2023 ; 15 (8): ? Nephropedia Template TP {{tp|p=37111149|t=2023. Effect of Thymbra capitata (L ) Cav on Inflammation, Senescence and Cell Migration |pdf=|usr=}}{{37111149}} gab.com Text Effect of Thymbra capitata (L ) Cav on Inflammation, Senescence and Cell Migration JO: Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=37111149 #FOAvip Aromatic plants are reported to display pharmacological properties, including anti-aging. This work aims to disclose the anti-aging effect of the essential oil (EO) of Thymbra capitata (L.) Cav., an aromatic and medicinal plant widely used as a spice, as well as of the hydrodistillation residual water (HRW), a discarded by-product of EO hydrodistillation. The phytochemical characterization of EO and HRW was assessed by GC-MS and HPLC-PDA-ESI-MS(n), respectively. The DPPH, ABTS, and FRAP assays were used to disclose the antioxidant properties. The anti-inflammatory potential was evaluated using lipopolysaccharide-stimulated macrophages by assessing NO production, iNOS, and pro-IL-1beta protein levels. Cell migration was evaluated using the scratch wound assay, and the etoposide-induced senescence was used to assess the modulation of senescence. The EO is mainly characterized by carvacrol, while the HRW is predominantly characterized by rosmarinic acid. The HRW exerts a stronger antioxidant effect in the DPPH and FRAP assays, whereas the EO was the most active sample in the ABTS assay. Both extracts reduce NO, iNOS, and pro-IL-1beta. The EO has no effect on cell migration and presents anti-senescence effects. In opposition, HRW reduces cell migration and induces cellular senescence. Overall, our study highlights interesting pharmacological properties for both extracts, EO being of interest as an anti-aging ingredient and HRW relevant in cancer therapy. Twit Text FOAVip Effect of Thymbra capitata (L ) Cav on Inflammation, Senescence and Cell Migration ????Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=37111149 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=37111149 #FOAvip English Wikipedia <ref>{{Cite pmid|37111149}}</ref> Effect of Thymbra capitata (L ) Cav on Inflammation, Senescence and Cell Migration #MMPMID37111149 Alves-Silva JM; Pedreiro S; Cavaleiro C; Cruz MT; Figueirinha A; Salgueiro L Nutrients 2023[Apr]; 15 (8): ? PMID37111149show ga Aromatic plants are reported to display pharmacological properties, including anti-aging. This work aims to disclose the anti-aging effect of the essential oil (EO) of Thymbra capitata (L.) Cav., an aromatic and medicinal plant widely used as a spice, as well as of the hydrodistillation residual water (HRW), a discarded by-product of EO hydrodistillation. The phytochemical characterization of EO and HRW was assessed by GC-MS and HPLC-PDA-ESI-MS(n), respectively. The DPPH, ABTS, and FRAP assays were used to disclose the antioxidant properties. The anti-inflammatory potential was evaluated using lipopolysaccharide-stimulated macrophages by assessing NO production, iNOS, and pro-IL-1beta protein levels. Cell migration was evaluated using the scratch wound assay, and the etoposide-induced senescence was used to assess the modulation of senescence. The EO is mainly characterized by carvacrol, while the HRW is predominantly characterized by rosmarinic acid. The HRW exerts a stronger antioxidant effect in the DPPH and FRAP assays, whereas the EO was the most active sample in the ABTS assay. Both extracts reduce NO, iNOS, and pro-IL-1beta. The EO has no effect on cell migration and presents anti-senescence effects. In opposition, HRW reduces cell migration and induces cellular senescence. Overall, our study highlights interesting pharmacological properties for both extracts, EO being of interest as an anti-aging ingredient and HRW relevant in cancer therapy. |*Lamiaceae/chemistry[MESH] |*Oils, Volatile/pharmacology[MESH] |Antioxidants/pharmacology/chemistry[MESH] |Inflammation/drug therapy[MESH] |Phytochemicals/pharmacology[MESH]Effect of Thymbra capitata (L ) Cav on Inflammation, Senescence and C(epmc).pdf DeepDyve Pubget Overpricing