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pmid3706491      Am+J+Pathol 1986 ; 123 (2): 301-9
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  • Immunohistochemical analysis of monoclonal antibodies to renal antigens Application in the diagnosis of renal cell carcinoma #MMPMID3706491
  • Oosterwijk E; Ruiter DJ; Wakka JC; Huiskens-van der Meij JW; Jonas U; Fleuren GJ; Zwartendijk J; Hoedemaeker P; Warnaar SO
  • Am J Pathol 1986[May]; 123 (2): 301-9 PMID3706491show ga
  • Four mouse monoclonal antibodies reacting with renal proximal epithelium were characterized on normal adult tissues, fetal kidneys, and various malignancies. These four antibodies were found to react with renal cell carcinomas (RCCs) but not with a variety of other tumors. Three antibodies react only with some primary RCCs and not with metastatic RCCs. The fourth antibody, RC 38, reacts with 46 of 47 primary RCCs tested and with 8 of 13 RCC metastases. No reaction was seen with 179 tumors of various origin, which indicates that this antibody is very useful in diagnosing RCC.
  • |*Antibodies, Monoclonal/biosynthesis[MESH]
  • |Adenoma/diagnosis/pathology[MESH]
  • |Animals[MESH]
  • |Carcinoma, Renal Cell/*diagnosis/pathology/secondary[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Fetus[MESH]
  • |Frozen Sections[MESH]
  • |Humans[MESH]
  • |Hybridomas[MESH]
  • |Kidney Neoplasms/*diagnosis/pathology/secondary[MESH]
  • |Kidney/immunology/pathology[MESH]
  • |Mice[MESH]


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