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10.3389/fphar.2023.1057144

http://scihub22266oqcxt.onion/10.3389/fphar.2023.1057144
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37021057!10067738!37021057
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suck abstract from ncbi

pmid37021057      Front+Pharmacol 2023 ; 14 (?): 1057144
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  • Role of curcumin in ischemia and reperfusion injury #MMPMID37021057
  • Bi M; Li D; Zhang J
  • Front Pharmacol 2023[]; 14 (?): 1057144 PMID37021057show ga
  • Ischemia-reperfusion injury (IRI) is an inevitable pathological process after organic transplantations. Although traditional treatments restore the blood supply of ischemic organs, the damage caused by IRI is always ignored. Therefore, the ideal and effective therapeutic strategy to mitigate IRI is warrented. Curcumin is a type of polyphenols, processing such properties as anti-oxidative stress, anti-inflammation and anti-apoptosis. However, although many researches have been confirmed that curcumin can exert great effects on the mitigation of IRI, there are still some controversies about its underlying mechanisms among these researches. Thus, this review is to summarize the protective role of curcumin against IRI as well as the controversies of current researches, so as to clarify its underlying mechanisms clearly and provide clinicians a novel idea of the therapy for IRI.
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