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10.3390/membranes13030286 http://scihub22266oqcxt.onion/10.3390/membranes13030286 36984673!10052067!36984673     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=36984673&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Membranes+(Basel) 2023 ; 13 (3): ? Nephropedia Template TP {{tp|p=36984673|t=2023. The Interplay between TRPM7 and MagT1 in Maintaining Endothelial Magnesium Homeostasis |pdf=|usr=}}{{36984673}} gab.com Text The Interplay between TRPM7 and MagT1 in Maintaining Endothelial Magnesium Homeostasis JO: Membranes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=36984673 #FOAvip The transient receptor potential cation channel subfamily M member 7 (TRPM7) is an ubiquitous channel fused to an alpha-kinase domain involved in magnesium (Mg) transport, and its level of expression has been proposed as a marker of endothelial function. To broaden our present knowledge about the role of TRPM7 in endothelial cells, we generated stable transfected Human Endothelial Cells derived from the Umbilical Vein (HUVEC). TRPM7-silencing HUVEC maintain the actin fibers' organization and mitochondrial network. They produce reduced amounts of reactive oxygen species and grow faster than controls. Intracellular Mg concentration does not change in TRPM7-silencing or -expressing HUVEC, while some differences emerged when we analyzed intracellular Mg distribution. While the levels of the plasma membrane Mg transporter Solute Carrier family 41 member 1 (SLC41A1) and the mitochondrial channel Mrs2 remain unchanged, the highly selective Magnesium Transporter 1 (MagT1) is upregulated in TRPM7-silencing HUVEC through transcriptional regulation. We propose that the increased amounts of MagT1 grant the maintenance of intracellular Mg concentrations when TRPM7 is not expressed in endothelial cells. Twit Text FOAVip The Interplay between TRPM7 and MagT1 in Maintaining Endothelial Magnesium Homeostasis ????Membranes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=36984673 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=36984673 #FOAvip English Wikipedia <ref>{{Cite pmid|36984673}}</ref> The Interplay between TRPM7 and MagT1 in Maintaining Endothelial Magnesium Homeostasis #MMPMID36984673 Castiglioni S; Locatelli L; Fedele G; Cazzaniga A; Malucelli E; Iotti S; Maier JA Membranes (Basel) 2023[Feb]; 13 (3): ? PMID36984673show ga The transient receptor potential cation channel subfamily M member 7 (TRPM7) is an ubiquitous channel fused to an alpha-kinase domain involved in magnesium (Mg) transport, and its level of expression has been proposed as a marker of endothelial function. To broaden our present knowledge about the role of TRPM7 in endothelial cells, we generated stable transfected Human Endothelial Cells derived from the Umbilical Vein (HUVEC). TRPM7-silencing HUVEC maintain the actin fibers' organization and mitochondrial network. They produce reduced amounts of reactive oxygen species and grow faster than controls. Intracellular Mg concentration does not change in TRPM7-silencing or -expressing HUVEC, while some differences emerged when we analyzed intracellular Mg distribution. While the levels of the plasma membrane Mg transporter Solute Carrier family 41 member 1 (SLC41A1) and the mitochondrial channel Mrs2 remain unchanged, the highly selective Magnesium Transporter 1 (MagT1) is upregulated in TRPM7-silencing HUVEC through transcriptional regulation. We propose that the increased amounts of MagT1 grant the maintenance of intracellular Mg concentrations when TRPM7 is not expressed in endothelial cells. ?The Interplay between TRPM7 and MagT1 in Maintaining Endothelial Magne(epmc).pdf DeepDyve Pubget Overpricing