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10.1186/s40478-023-01526-9 http://scihub22266oqcxt.onion/10.1186/s40478-023-01526-9 36915214!10009953!36915214     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=36915214&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Acta+Neuropathol+Commun 2023 ; 11 (1): 42 Nephropedia Template TP {{tp|p=36915214|t=2023. Roles of neuropathology-associated reactive astrocytes: a systematic review |pdf=|usr=}}{{36915214}} gab.com Text Roles of neuropathology-associated reactive astrocytes: a systematic review JO: Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=36915214 #FOAvip In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-alpha, IL-1alpha, and C1q induces a neurotoxic astrocytic phenotype, classified as A1, A1-like, or neuroinflammatory reactive astrocytes. In contrast to typical astrocytes, which promote neuronal survival, support synapses, and maintain blood-brain barrier integrity, these reactive astrocytes downregulate supportive functions and begin to secrete neurotoxic factors, complement components like C3, and chemokines like CXCL10, which may facilitate recruitment of immune cells across the BBB into the CNS. The proportion of pro-inflammatory reactive astrocytes increases with age through associated microglia activation, and these pro-inflammatory reactive astrocytes are particularly abundant in neurodegenerative disorders. As the identification of astrocyte phenotypes progress, their molecular and cellular effects are characterized in a growing array of neuropathologies. Twit Text FOAVip Roles of neuropathology-associated reactive astrocytes: a systematic review ????Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=36915214 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=36915214 #FOAvip English Wikipedia <ref>{{Cite pmid|36915214}}</ref> Roles of neuropathology-associated reactive astrocytes: a systematic review #MMPMID36915214 Lawrence JM; Schardien K; Wigdahl B; Nonnemacher MR Acta Neuropathol Commun 2023[Mar]; 11 (1): 42 PMID36915214show ga In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-alpha, IL-1alpha, and C1q induces a neurotoxic astrocytic phenotype, classified as A1, A1-like, or neuroinflammatory reactive astrocytes. In contrast to typical astrocytes, which promote neuronal survival, support synapses, and maintain blood-brain barrier integrity, these reactive astrocytes downregulate supportive functions and begin to secrete neurotoxic factors, complement components like C3, and chemokines like CXCL10, which may facilitate recruitment of immune cells across the BBB into the CNS. The proportion of pro-inflammatory reactive astrocytes increases with age through associated microglia activation, and these pro-inflammatory reactive astrocytes are particularly abundant in neurodegenerative disorders. As the identification of astrocyte phenotypes progress, their molecular and cellular effects are characterized in a growing array of neuropathologies. |*Astrocytes/metabolism[MESH] |*Neurotoxicity Syndromes/pathology[MESH] |Blood-Brain Barrier/metabolism[MESH] |Central Nervous System/metabolism[MESH] |Chemokines/metabolism[MESH] |Humans[MESH]Roles of neuropathology-associated reactive astrocytes: a systematic r(epmc).pdf DeepDyve Pubget Overpricing