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10.3389/fonc.2022.1065935 http://scihub22266oqcxt.onion/10.3389/fonc.2022.1065935 36844925!9948629!36844925     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=36844925&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Front+Oncol 2022 ; 12 (?): 1065935 Nephropedia Template TP {{tp|p=36844925|t=2022. On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications |pdf=|usr=}}{{36844925}} gab.com Text On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications JO: Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=36844925 #FOAvip The transient melastatin receptor potential (TRPM) ion channel subfamily functions as cellular sensors and transducers of critical biological signal pathways by regulating ion homeostasis. Some members of TRPM have been cloned from cancerous tissues, and their abnormal expressions in various solid malignancies have been correlated with cancer cell growth, survival, or death. Recent evidence also highlights the mechanisms underlying the role of TRPMs in tumor epithelial-mesenchymal transition (EMT), autophagy, and cancer metabolic reprogramming. These implications support TRPM channels as potential molecular targets and their modulation as an innovative therapeutic approach against cancer. Here, we discuss the general characteristics of the different TRPMs, focusing on current knowledge about the connection between TRPM channels and critical features of cancer. We also cover TRPM modulators used as pharmaceutical tools in biological trials and an indication of the only clinical trial with a TRPM modulator about cancer. To conclude, the authors describe the prospects for TRPM channels in oncology. Twit Text FOAVip On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications ????Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=36844925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=36844925 #FOAvip English Wikipedia <ref>{{Cite pmid|36844925}}</ref> On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications #MMPMID36844925 Ciaglia T; Vestuto V; Bertamino A; Gonzalez-Muniz R; Gomez-Monterrey I Front Oncol 2022[]; 12 (?): 1065935 PMID36844925show ga The transient melastatin receptor potential (TRPM) ion channel subfamily functions as cellular sensors and transducers of critical biological signal pathways by regulating ion homeostasis. Some members of TRPM have been cloned from cancerous tissues, and their abnormal expressions in various solid malignancies have been correlated with cancer cell growth, survival, or death. Recent evidence also highlights the mechanisms underlying the role of TRPMs in tumor epithelial-mesenchymal transition (EMT), autophagy, and cancer metabolic reprogramming. These implications support TRPM channels as potential molecular targets and their modulation as an innovative therapeutic approach against cancer. Here, we discuss the general characteristics of the different TRPMs, focusing on current knowledge about the connection between TRPM channels and critical features of cancer. We also cover TRPM modulators used as pharmaceutical tools in biological trials and an indication of the only clinical trial with a TRPM modulator about cancer. To conclude, the authors describe the prospects for TRPM channels in oncology. ?On the modulation of TRPM channels: Current perspectives and anticance(epmc).pdf DeepDyve Pubget Overpricing