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10.1126/sciadv.abo1461 http://scihub22266oqcxt.onion/10.1126/sciadv.abo1461 36351022!9645726!36351022     free     free     free       Sci+Adv 2022 ; 8 (45): eabo1461 Nephropedia Template TP {{tp|p=36351022|t=2022. Force- and cell state-dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry |pdf=|usr=}}{{36351022}} gab.com Text Force- and cell state-dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=36351022 #FOAvip Mechanosensing is an integral part of many physiological processes including stem cell differentiation, fibrosis, and cancer progression. Two major mechanosensing systems-focal adhesions and mechanosensitive ion channels-can convert mechanical features of the microenvironment into biochemical signals. We report here unexpectedly that the mechanosensitive calcium-permeable channel Piezo1, previously perceived to be diffusive on plasma membranes, binds to matrix adhesions in a force-dependent manner, promoting cell spreading, adhesion dynamics, and calcium entry in normal but not in most cancer cells tested except some glioblastoma lines. A linker domain in Piezo1 is needed for binding to adhesions, and overexpression of the domain blocks Piezo1 binding to adhesions, decreasing adhesion size and cell spread area. Thus, we suggest that Piezo1 is a previously unidentified component of focal adhesions in nontransformed cells that catalyzes adhesion maturation and growth through force-dependent calcium signaling, but this function is absent in most cancer cells. Twit Text FOAVip Force- and cell state-dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=36351022 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=36351022 #FOAvip English Wikipedia <ref>{{Cite pmid|36351022}}</ref> Force- and cell state-dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry #MMPMID36351022 Yao M; Tijore A; Cheng D; Li JV; Hariharan A; Martinac B; Tran Van Nhieu G; Cox CD; Sheetz M Sci Adv 2022[Nov]; 8 (45): eabo1461 PMID36351022show ga Mechanosensing is an integral part of many physiological processes including stem cell differentiation, fibrosis, and cancer progression. Two major mechanosensing systems-focal adhesions and mechanosensitive ion channels-can convert mechanical features of the microenvironment into biochemical signals. We report here unexpectedly that the mechanosensitive calcium-permeable channel Piezo1, previously perceived to be diffusive on plasma membranes, binds to matrix adhesions in a force-dependent manner, promoting cell spreading, adhesion dynamics, and calcium entry in normal but not in most cancer cells tested except some glioblastoma lines. A linker domain in Piezo1 is needed for binding to adhesions, and overexpression of the domain blocks Piezo1 binding to adhesions, decreasing adhesion size and cell spread area. Thus, we suggest that Piezo1 is a previously unidentified component of focal adhesions in nontransformed cells that catalyzes adhesion maturation and growth through force-dependent calcium signaling, but this function is absent in most cancer cells. ?Force- and cell state-dependent recruitment of Piezo1 drives focal adh(epmc).pdf DeepDyve Pubget Overpricing