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10.1007/s00284-022-02971-w

http://scihub22266oqcxt.onion/10.1007/s00284-022-02971-w
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35907089!9362411!35907089
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suck abstract from ncbi


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pmid35907089      Curr+Microbiol 2022 ; 79 (9): 275
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  • Induction of Cross-Reacting Antibodies Against the COVID-19 by BCG Vaccination in the Mouse Model #MMPMID35907089
  • Rahali N; Bahloul C
  • Curr Microbiol 2022[Jul]; 79 (9): 275 PMID35907089show ga
  • It was reported that tuberculosis and BCG vaccination are potential tools for reducing the burden of COVID-19, mainly through the non-specific trained immunity. We have investigated whether BCG vaccination is able to induce cross-reacting antibodies against the SARS-CoV-2. We have tested the induced humoral immune responses against the SARS-CoV-2 Spike in the mouse model, after either BCG or rabies DNA-based vaccination alone or in Prime/Boost approach to COVID-19 DNA-based vaccination. We have demonstrated that BCG vaccination alone was able to induce cross-reacting antibodies to SARS-CoV-2 Spike. It can also boost the antibody response induced by a COVID-19 DNA-based vaccination. Hence, both BCG and latent tuberculosis infection can explain the lower burden of COVID-19 in developing countries, not only through the trained immunity but also by inducing cross-reacting antibodies. Furthermore, with the emergence of different COVID-19 variants, or eventually other Betacoronaviruses, the use of BCG vaccination can help against immune escapes of the current vaccines.
  • |*COVID-19/prevention & control[MESH]
  • |Animals[MESH]
  • |Antibodies, Viral[MESH]
  • |BCG Vaccine[MESH]
  • |Disease Models, Animal[MESH]
  • |Mice[MESH]
  • |SARS-CoV-2[MESH]


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