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10.1016/j.eimce.2022.07.006

http://scihub22266oqcxt.onion/10.1016/j.eimce.2022.07.006
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35906174!9315338!35906174
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suck abstract from ncbi


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pmid35906174      Enferm+Infecc+Microbiol+Clin+(Engl+Ed) 2023 ; 41 (5): 301-304
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  • The new generation of messenger RNA (mRNA) vaccines against influenza #MMPMID35906174
  • Reina J
  • Enferm Infecc Microbiol Clin (Engl Ed) 2023[May]; 41 (5): 301-304 PMID35906174show ga
  • Today there are multiple types of flu vaccines. The emergence of nucleic acid technology used in vaccines against SARS-CoV-2 suggests its future application against this infection. Against influenza, two types of vaccines have been developed based on messenger RNA (mRNA): conventional or non-replicative and self-amplifying or replicative (auRNA), both included in lipid nanoparticles. Animal studies carried out with the former have shown their strong capacity to induce Th-1 antibodies and cellular immunity against influenza haemagglutinin (HA) with few side effects. Human trials have shown 87% seroconversion and 100% seroprotection. The auRNA vaccines have obtained similar results in animals but at a concentration 64 times lower than the conventional one. Vaccines based on mRNA platforms meet the WHO requirements for next generation influenza vaccines.
  • |*COVID-19/prevention & control[MESH]
  • |*Influenza Vaccines[MESH]
  • |*Influenza, Human/prevention & control[MESH]
  • |Animals[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Humans[MESH]
  • |RNA, Messenger/genetics[MESH]
  • |SARS-CoV-2[MESH]


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