Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.2203437119 http://scihub22266oqcxt.onion/10.1073/pnas.2203437119 35895716!9388124!35895716     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35895716&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Proc+Natl+Acad+Sci+U+S+A 2022 ; 119 (33): e2203437119 Nephropedia Template TP {{tp|p=35895716|t=2022. Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity |pdf=|usr=}}{{35895716}} gab.com Text Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=35895716 #FOAvip The mortality of coronavirus disease 2019 (COVID-19) is strongly correlated with pulmonary vascular pathology accompanied by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-triggered immune dysregulation and aberrant activation of platelets. We combined histological analyses using field emission scanning electron microscopy with energy-dispersive X-ray spectroscopy analyses of the lungs from autopsy samples and single-cell RNA sequencing of peripheral blood mononuclear cells to investigate the pathogenesis of vasculitis and immunothrombosis in COVID-19. We found that SARS-CoV-2 accumulated in the pulmonary vessels, causing exudative vasculitis accompanied by the emergence of thrombospondin-1-expressing noncanonical monocytes and the formation of myosin light chain 9 (Myl9)-containing microthrombi in the lung of COVID-19 patients with fatal disease. The amount of plasma Myl9 in COVID-19 was correlated with the clinical severity, and measuring plasma Myl9 together with other markers allowed us to predict the severity of the disease more accurately. This study provides detailed insight into the pathogenesis of vasculitis and immunothrombosis, which may lead to optimal medical treatment for COVID-19. Twit Text FOAVip Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=35895716 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35895716 #FOAvip English Wikipedia <ref>{{Cite pmid|35895716}}</ref> Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity #MMPMID35895716 Iwamura C; Hirahara K; Kiuchi M; Ikehara S; Azuma K; Shimada T; Kuriyama S; Ohki S; Yamamoto E; Inaba Y; Shiko Y; Aoki A; Kokubo K; Hirasawa R; Hishiya T; Tsuji K; Nagaoka T; Ishikawa S; Kojima A; Mito H; Hase R; Kasahara Y; Kuriyama N; Tsukamoto T; Nakamura S; Urushibara T; Kaneda S; Sakao S; Tobiume M; Suzuki Y; Tsujiwaki M; Kubo T; Hasegawa T; Nakase H; Nishida O; Takahashi K; Baba K; Iizumi Y; Okazaki T; Kimura MY; Yoshino I; Igari H; Nakajima H; Suzuki T; Hanaoka H; Nakada TA; Ikehara Y; Yokote K; Nakayama T Proc Natl Acad Sci U S A 2022[Aug]; 119 (33): e2203437119 PMID35895716show ga The mortality of coronavirus disease 2019 (COVID-19) is strongly correlated with pulmonary vascular pathology accompanied by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-triggered immune dysregulation and aberrant activation of platelets. We combined histological analyses using field emission scanning electron microscopy with energy-dispersive X-ray spectroscopy analyses of the lungs from autopsy samples and single-cell RNA sequencing of peripheral blood mononuclear cells to investigate the pathogenesis of vasculitis and immunothrombosis in COVID-19. We found that SARS-CoV-2 accumulated in the pulmonary vessels, causing exudative vasculitis accompanied by the emergence of thrombospondin-1-expressing noncanonical monocytes and the formation of myosin light chain 9 (Myl9)-containing microthrombi in the lung of COVID-19 patients with fatal disease. The amount of plasma Myl9 in COVID-19 was correlated with the clinical severity, and measuring plasma Myl9 together with other markers allowed us to predict the severity of the disease more accurately. This study provides detailed insight into the pathogenesis of vasculitis and immunothrombosis, which may lead to optimal medical treatment for COVID-19. |*COVID-19/blood/complications/pathology[MESH] |*Lung/blood supply/metabolism/pathology/virology[MESH] |*Myosin Light Chains/blood[MESH] |*SARS-CoV-2/isolation & purification[MESH] |*Severity of Illness Index[MESH] |*Thromboinflammation/pathology/virology[MESH] |*Vasculitis/pathology/virology[MESH] |Humans[MESH] |Leukocytes, Mononuclear[MESH] |RNA-Seq[MESH] |Single-Cell Analysis[MESH]Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-(epmc).pdf DeepDyve Pubget Overpricing