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10.3390/jcm11144006 http://scihub22266oqcxt.onion/10.3390/jcm11144006 35887770!9317441!35887770     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35887770&cmd=llinks): Failed to open stream: HTTP request failed! 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Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease |pdf=|usr=}}{{35887770}} gab.com Text Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease JO: J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=35887770 #FOAvip Coagulopathy in COVID-19 patients is presumably based on systemic hypercoagulation with the inflammatory response. As a result of endothelial dysfunction, tissue factor and von Willebrand factor (vWF) are released into the blood stream, which leads to prothrombinase activation. The vWF/ADAMTS-13 ratio can be used for monitoring the severity of the disease. This observational prospective study included 141 patients with COVID-19. In patients with mild COVID-19 (group 1), the assessment was performed on the 3rd-7th day of illness (point 1) and 14-28 days after recovery (point 2). In patients with moderate (groups 2) and severe (group 3) COVID-19, the assessment was performed during hospitalization (point 1) and after 14 days (point 2). The vWF:RCo/ADAMTS-13:activity (point 1), vWF/ADAMTS-13 (point 2) and vWF:RCo/ADAMTS-13:activity (point 2) ratios were significantly higher in patients with moderate and severe COVID-19. Moreover, in these patients, both ratios increased after recovery (point 2), which is a negative prognostic factor of thrombotic complications. Thus, COVID-19 is characterized by a decrease in the concentration and activity of ADAMTS-13 metalloproteinase, especially in patients with the severe form of COVID-19. A decrease in ADAMTS-13 activity results in an increase in vWF concentration and activity so the ratio of vWF to ADAMTS-13 changes significantly. Twit Text FOAVip Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease ????J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=35887770 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35887770 #FOAvip English Wikipedia <ref>{{Cite pmid|35887770}}</ref> Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease #MMPMID35887770 Dolgushina N; Gorodnova E; Beznoshenco O; Romanov A; Menzhinskaya I; Krechetova L; Sukhikh G J Clin Med 2022[Jul]; 11 (14): ä PMID35887770show ga Coagulopathy in COVID-19 patients is presumably based on systemic hypercoagulation with the inflammatory response. As a result of endothelial dysfunction, tissue factor and von Willebrand factor (vWF) are released into the blood stream, which leads to prothrombinase activation. The vWF/ADAMTS-13 ratio can be used for monitoring the severity of the disease. This observational prospective study included 141 patients with COVID-19. In patients with mild COVID-19 (group 1), the assessment was performed on the 3rd-7th day of illness (point 1) and 14-28 days after recovery (point 2). In patients with moderate (groups 2) and severe (group 3) COVID-19, the assessment was performed during hospitalization (point 1) and after 14 days (point 2). The vWF:RCo/ADAMTS-13:activity (point 1), vWF/ADAMTS-13 (point 2) and vWF:RCo/ADAMTS-13:activity (point 2) ratios were significantly higher in patients with moderate and severe COVID-19. Moreover, in these patients, both ratios increased after recovery (point 2), which is a negative prognostic factor of thrombotic complications. Thus, COVID-19 is characterized by a decrease in the concentration and activity of ADAMTS-13 metalloproteinase, especially in patients with the severe form of COVID-19. A decrease in ADAMTS-13 activity results in an increase in vWF concentration and activity so the ratio of vWF to ADAMTS-13 changes significantly. äVon Willebrand Factor and ADAMTS-13 Are Associated with the Severity o(epmc).pdf DeepDyve Pubget Overpricing