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10.1038/s41598-022-15969-y http://scihub22266oqcxt.onion/10.1038/s41598-022-15969-y 35869087!9305055!35869087     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35869087&cmd=llinks): Failed to open stream: HTTP request failed! 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Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19 |pdf=|usr=}}{{35869087}} gab.com Text Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=35869087 #FOAvip Whereas the detection of antiphospholipid autoantibodies (aPL) in COVID-19 is of increasing interest, their role is still unclear. We analyzed a large aPL panel in 157 patients with COVID-19 according to the disease severity. We also investigated a potential association between aPL and extracellular DNA (exDNA, n = 85) or circulating markers of neutrophil extracellular traps (NET) such as citrullinated histones H3 (CitH3, n = 49). A total of 157 sera of patients infected by SARS-CoV-2 were collected. A large aPL panel including lupus anticoagulant, anti-cardiolipin and anti-beta-2 glycoprotein I (IgG, IgM and IgA), anti-phosphatidylethanolamine IgA, anti-prothrombin (IgG and IgM) was retrospectively analyzed according to the disease severity. We found a total aPL prevalence of 54.8% with almost half of the cases having aCL IgG. Within an extended panel of aPL, only aCL IgG were associated with COVID-19 severity. Additionally, severe patients displayed higher CitH3 levels than mild patients. Interestingly, we highlighted a significant association between the levels of aCL IgG and exDNA only in aCL positive patients with severe disease. In conclusion, we showed a significant link between aPL, namely aCL IgG, and circulating exDNA in patients with severe form of COVID-19, that could exacerbate the thrombo-inflammatory state related to disease severity. Twit Text FOAVip Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=35869087 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35869087 #FOAvip English Wikipedia <ref>{{Cite pmid|35869087}}</ref> Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19 #MMPMID35869087 Bertin D; Brodovitch A; Lopez A; Arcani R; Thomas GM; Beziane A; Weber S; Babacci B; Heim X; Rey L; Leone M; Mege JL; Bardin N Sci Rep 2022[Jul]; 12 (1): 12523 PMID35869087show ga Whereas the detection of antiphospholipid autoantibodies (aPL) in COVID-19 is of increasing interest, their role is still unclear. We analyzed a large aPL panel in 157 patients with COVID-19 according to the disease severity. We also investigated a potential association between aPL and extracellular DNA (exDNA, n = 85) or circulating markers of neutrophil extracellular traps (NET) such as citrullinated histones H3 (CitH3, n = 49). A total of 157 sera of patients infected by SARS-CoV-2 were collected. A large aPL panel including lupus anticoagulant, anti-cardiolipin and anti-beta-2 glycoprotein I (IgG, IgM and IgA), anti-phosphatidylethanolamine IgA, anti-prothrombin (IgG and IgM) was retrospectively analyzed according to the disease severity. We found a total aPL prevalence of 54.8% with almost half of the cases having aCL IgG. Within an extended panel of aPL, only aCL IgG were associated with COVID-19 severity. Additionally, severe patients displayed higher CitH3 levels than mild patients. Interestingly, we highlighted a significant association between the levels of aCL IgG and exDNA only in aCL positive patients with severe disease. In conclusion, we showed a significant link between aPL, namely aCL IgG, and circulating exDNA in patients with severe form of COVID-19, that could exacerbate the thrombo-inflammatory state related to disease severity. |*Antiphospholipid Syndrome[MESH] |*COVID-19[MESH] |*Cell-Free Nucleic Acids[MESH] |Antibodies, Anticardiolipin[MESH] |Antibodies, Antiphospholipid[MESH] |Autoantibodies[MESH] |Humans[MESH] |Immunoglobulin A[MESH] |Immunoglobulin G[MESH] |Immunoglobulin M[MESH] |Retrospective Studies[MESH]Anti-cardiolipin IgG autoantibodies associate with circulating extrace(epmc).pdf DeepDyve Pubget Overpricing