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10.1093/brain/awac272 http://scihub22266oqcxt.onion/10.1093/brain/awac272 35867861!9384509!35867861     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35867861&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brain 2023 ; 146 (2): 727-738 Nephropedia Template TP {{tp|p=35867861|t=2023. SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction |pdf=|usr=}}{{35867861}} gab.com Text SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction JO: Brain http://www.kidney.de/pget.php?&tw=1&pmid=35867861 #FOAvip The SARS-CoV-2 receptor, ACE2, is found on pericytes, contractile cells enwrapping capillaries that regulate brain, heart and kidney blood flow. ACE2 converts vasoconstricting angiotensin II into vasodilating angiotensin-(1-7). In brain slices from hamster, which has an ACE2 sequence similar to human ACE2, angiotensin II evoked a small pericyte-mediated capillary constriction via AT1 receptors, but evoked a large constriction when the SARS-CoV-2 receptor binding domain (RBD, original Wuhan variant) was present. A mutated non-binding RBD did not potentiate constriction. A similar RBD-potentiated capillary constriction occurred in human cortical slices, and was evoked in hamster brain slices by pseudotyped virions expressing SARS-CoV-2 spike protein. This constriction reflects an RBD-induced decrease in the conversion of angiotensin II to angiotensin-(1-7) mediated by removal of ACE2 from the cell surface membrane and was mimicked by blocking ACE2. The clinically used drug losartan inhibited the RBD-potentiated constriction. Thus, AT1 receptor blockers could be protective in COVID-19 by preventing pericyte-mediated blood flow reductions in the brain, and perhaps the heart and kidney. Twit Text FOAVip SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction ????Brain http://www.kidney.de/pget.php?&tw=1&pmid=35867861 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35867861 #FOAvip English Wikipedia <ref>{{Cite pmid|35867861}}</ref> SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction #MMPMID35867861 Hirunpattarasilp C; James G; Kwanthongdee J; Freitas F; Huo J; Sethi H; Kittler JT; Owens RJ; McCoy LE; Attwell D Brain 2023[Feb]; 146 (2): 727-738 PMID35867861show ga The SARS-CoV-2 receptor, ACE2, is found on pericytes, contractile cells enwrapping capillaries that regulate brain, heart and kidney blood flow. ACE2 converts vasoconstricting angiotensin II into vasodilating angiotensin-(1-7). In brain slices from hamster, which has an ACE2 sequence similar to human ACE2, angiotensin II evoked a small pericyte-mediated capillary constriction via AT1 receptors, but evoked a large constriction when the SARS-CoV-2 receptor binding domain (RBD, original Wuhan variant) was present. A mutated non-binding RBD did not potentiate constriction. A similar RBD-potentiated capillary constriction occurred in human cortical slices, and was evoked in hamster brain slices by pseudotyped virions expressing SARS-CoV-2 spike protein. This constriction reflects an RBD-induced decrease in the conversion of angiotensin II to angiotensin-(1-7) mediated by removal of ACE2 from the cell surface membrane and was mimicked by blocking ACE2. The clinically used drug losartan inhibited the RBD-potentiated constriction. Thus, AT1 receptor blockers could be protective in COVID-19 by preventing pericyte-mediated blood flow reductions in the brain, and perhaps the heart and kidney. |*COVID-19/metabolism[MESH] |*SARS-CoV-2/metabolism[MESH] |Angiotensin II/pharmacology/metabolism[MESH] |Angiotensin-Converting Enzyme 2/chemistry/metabolism[MESH] |Capillaries[MESH] |Constriction[MESH] |Humans[MESH] |Peptidyl-Dipeptidase A/genetics/metabolism[MESH] |Pericytes/metabolism[MESH] |Protein Binding[MESH]SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction (epmc).pdf DeepDyve Pubget Overpricing