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10.1007/s00424-022-02726-3 http://scihub22266oqcxt.onion/10.1007/s00424-022-02726-3 35867189!9304794!35867189     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pflugers+Arch 2022 ; 474 (10): 1069-1076 Nephropedia Template TP {{tp|p=35867189|t=2022. Mineralocorticoid receptor-antagonism prevents COVID-19-dependent glycocalyx damage |pdf=|usr=}}{{35867189}} gab.com Text Mineralocorticoid receptor-antagonism prevents COVID-19-dependent glycocalyx damage JO: Pflugers Arch http://www.kidney.de/pget.php?&tw=1&pmid=35867189 #FOAvip Proinflammatory cytokines target vascular endothelial cells during COVID-19 infections. In particular, the endothelial glycocalyx (eGC), a proteoglycan-rich layer on top of endothelial cells, was identified as a vulnerable, vasoprotective structure during infections. Thus, eGC damage can be seen as a hallmark in the development of endothelial dysfunction and inflammatory processes. Using sera derived from patients suffering from COVID-19, we could demonstrate that the eGC became progressively worse in relation to disease severity (mild vs severe course) and in correlation to IL-6 levels. This could be prevented by administering low doses of spironolactone, a well-known and highly specific aldosterone receptor antagonist. Our results confirm that SARS-CoV-2 infections cause eGC damage and endothelial dysfunction and we outline the underlying mechanisms and suggest potential therapeutic options. Twit Text FOAVip Mineralocorticoid receptor-antagonism prevents COVID-19-dependent glycocalyx damage ????Pflugers Arch http://www.kidney.de/pget.php?&tw=1&pmid=35867189 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35867189 #FOAvip English Wikipedia <ref>{{Cite pmid|35867189}}</ref> Mineralocorticoid receptor-antagonism prevents COVID-19-dependent glycocalyx damage #MMPMID35867189 Fels B; Acharya S; Vahldieck C; Graf T; Kading N; Rupp J; Kusche-Vihrog K Pflugers Arch 2022[Oct]; 474 (10): 1069-1076 PMID35867189show ga Proinflammatory cytokines target vascular endothelial cells during COVID-19 infections. In particular, the endothelial glycocalyx (eGC), a proteoglycan-rich layer on top of endothelial cells, was identified as a vulnerable, vasoprotective structure during infections. Thus, eGC damage can be seen as a hallmark in the development of endothelial dysfunction and inflammatory processes. Using sera derived from patients suffering from COVID-19, we could demonstrate that the eGC became progressively worse in relation to disease severity (mild vs severe course) and in correlation to IL-6 levels. This could be prevented by administering low doses of spironolactone, a well-known and highly specific aldosterone receptor antagonist. Our results confirm that SARS-CoV-2 infections cause eGC damage and endothelial dysfunction and we outline the underlying mechanisms and suggest potential therapeutic options. |*COVID-19 Drug Treatment[MESH] |*COVID-19/blood/pathology[MESH] |*Glycocalyx/drug effects/pathology[MESH] |*Mineralocorticoid Receptor Antagonists/pharmacology/therapeutic use[MESH] |*SARS-CoV-2[MESH] |*Spironolactone/pharmacology/therapeutic use[MESH] |Cytokines/pharmacology[MESH] |Endothelial Cells/drug effects/pathology[MESH] |Humans[MESH] |Interleukin-6/blood[MESH]Mineralocorticoid receptor-antagonism prevents COVID-19-dependent glyc(epmc).pdf DeepDyve Pubget Overpricing