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10.1021/acschembio.2c00176 http://scihub22266oqcxt.onion/10.1021/acschembio.2c00176 35861660!10597057!35861660     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Biol 2022 ; 17 (8): 2109-2120 Nephropedia Template TP {{tp|p=35861660|t=2022. S-Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs |pdf=|usr=}}{{35861660}} gab.com Text S-Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs JO: ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=35861660 #FOAvip Interferon-induced transmembrane proteins (IFITM1, 2, and 3) are important antiviral proteins that are active against many viruses, including influenza A virus (IAV), dengue virus (DENV), Ebola virus (EBOV), Zika virus (ZIKV), and severe acute respiratory syndrome coronavirus (SARS-CoV). IFITM proteins exhibit specificity in activity, but their distinct mechanisms of action and regulation are unclear. Since S-palmitoylation and cholesterol homeostasis are crucial for viral infections, we investigated IFITM interactions with cholesterol by photoaffinity cross-linking in mammalian cells along with molecular dynamic simulations and nuclear magnetic resonance analysis in vitro. These studies suggest that cholesterol can directly interact with S-palmitoylated IFITMs in cells and alter the conformation of IFITMs in membrane bilayers. Notably, we discovered that the S-palmitoylation levels regulate differential IFITM protein interactions with cholesterol in mammalian cells and specificity of antiviral activity toward IAV, SARS-CoV-2, and EBOV. Our studies suggest that modulation of IFITM S-palmitoylation levels and cholesterol interaction influence host susceptibility to different viruses. Twit Text FOAVip S-Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs ????ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=35861660 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35861660 #FOAvip English Wikipedia <ref>{{Cite pmid|35861660}}</ref> S-Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs #MMPMID35861660 Das T; Yang X; Lee H; Garst EH; Valencia E; Chandran K; Im W; Hang HC ACS Chem Biol 2022[Aug]; 17 (8): 2109-2120 PMID35861660show ga Interferon-induced transmembrane proteins (IFITM1, 2, and 3) are important antiviral proteins that are active against many viruses, including influenza A virus (IAV), dengue virus (DENV), Ebola virus (EBOV), Zika virus (ZIKV), and severe acute respiratory syndrome coronavirus (SARS-CoV). IFITM proteins exhibit specificity in activity, but their distinct mechanisms of action and regulation are unclear. Since S-palmitoylation and cholesterol homeostasis are crucial for viral infections, we investigated IFITM interactions with cholesterol by photoaffinity cross-linking in mammalian cells along with molecular dynamic simulations and nuclear magnetic resonance analysis in vitro. These studies suggest that cholesterol can directly interact with S-palmitoylated IFITMs in cells and alter the conformation of IFITMs in membrane bilayers. Notably, we discovered that the S-palmitoylation levels regulate differential IFITM protein interactions with cholesterol in mammalian cells and specificity of antiviral activity toward IAV, SARS-CoV-2, and EBOV. Our studies suggest that modulation of IFITM S-palmitoylation levels and cholesterol interaction influence host susceptibility to different viruses. |*Antiviral Agents/pharmacology[MESH] |*Lipoylation[MESH] |*Membrane Proteins/metabolism/pharmacology[MESH] |*Sterols/metabolism[MESH] |Animals[MESH] |Cholesterol/metabolism[MESH] |Influenza A virus[MESH] |SARS-CoV-2[MESH]S-Palmitoylation and Sterol Interactions Mediate Antiviral Specificity(epmc).pdf DeepDyve Pubget Overpricing