Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1080/19585969.2022.2046978 http://scihub22266oqcxt.onion/10.1080/19585969.2022.2046978 35860171!9286746!35860171     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dialogues+Clin+Neurosci 2021 ; 23 (1): 14-28 Nephropedia Template TP {{tp|p=35860171|t=2021. Blood metabolic signatures of hikikomori, pathological social withdrawal |pdf=|usr=}}{{35860171}} gab.com Text Blood metabolic signatures of hikikomori, pathological social withdrawal JO: Dialogues Clin Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=35860171 #FOAvip BACKGROUND: A severe form of pathological social withdrawal, 'hikikomori,' has been acknowledged in Japan, spreading worldwide, and becoming a global health issue. The pathophysiology of hikikomori has not been clarified, and its biological traits remain unexplored. METHODS: Drug-free patients with hikikomori (n = 42) and healthy controls (n = 41) were recruited. Psychological assessments for the severity of hikikomori and depression were conducted. Blood biochemical tests and plasma metabolome analysis were performed. Based on the integrated information, machine-learning models were created to discriminate cases of hikikomori from healthy controls, predict hikikomori severity, stratify the cases, and identify metabolic signatures that contribute to each model. RESULTS: Long-chain acylcarnitine levels were remarkably higher in patients with hikikomori; bilirubin, arginine, ornithine, and serum arginase were significantly different in male patients with hikikomori. The discriminative random forest model was highly performant, exhibiting an area under the ROC curve of 0.854 (confidential interval = 0.648-1.000). To predict hikikomori severity, a partial least squares PLS-regression model was successfully created with high linearity and practical accuracy. In addition, blood serum uric acid and plasma cholesterol esters contributed to the stratification of cases. CONCLUSIONS: These findings reveal the blood metabolic signatures of hikikomori, which are key to elucidating the pathophysiology of hikikomori and also useful as an index for monitoring the treatment course for rehabilitation. Twit Text FOAVip Blood metabolic signatures of hikikomori, pathological social withdrawal ????Dialogues Clin Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=35860171 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35860171 #FOAvip English Wikipedia <ref>{{Cite pmid|35860171}}</ref> Blood metabolic signatures of hikikomori, pathological social withdrawal #MMPMID35860171 Setoyama D; Matsushima T; Hayakawa K; Nakao T; Kanba S; Kang D; Kato TA Dialogues Clin Neurosci 2021[]; 23 (1): 14-28 PMID35860171show ga BACKGROUND: A severe form of pathological social withdrawal, 'hikikomori,' has been acknowledged in Japan, spreading worldwide, and becoming a global health issue. The pathophysiology of hikikomori has not been clarified, and its biological traits remain unexplored. METHODS: Drug-free patients with hikikomori (n = 42) and healthy controls (n = 41) were recruited. Psychological assessments for the severity of hikikomori and depression were conducted. Blood biochemical tests and plasma metabolome analysis were performed. Based on the integrated information, machine-learning models were created to discriminate cases of hikikomori from healthy controls, predict hikikomori severity, stratify the cases, and identify metabolic signatures that contribute to each model. RESULTS: Long-chain acylcarnitine levels were remarkably higher in patients with hikikomori; bilirubin, arginine, ornithine, and serum arginase were significantly different in male patients with hikikomori. The discriminative random forest model was highly performant, exhibiting an area under the ROC curve of 0.854 (confidential interval = 0.648-1.000). To predict hikikomori severity, a partial least squares PLS-regression model was successfully created with high linearity and practical accuracy. In addition, blood serum uric acid and plasma cholesterol esters contributed to the stratification of cases. CONCLUSIONS: These findings reveal the blood metabolic signatures of hikikomori, which are key to elucidating the pathophysiology of hikikomori and also useful as an index for monitoring the treatment course for rehabilitation. |*Phobia, Social[MESH] |*Social Isolation/psychology[MESH] |Humans[MESH] |Japan[MESH] |Male[MESH] |Shame[MESH]Blood metabolic signatures of hikikomori, pathological social withdraw(epmc).pdf DeepDyve Pubget Overpricing