Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/sciadv.abo0171 http://scihub22266oqcxt.onion/10.1126/sciadv.abo0171 35857849!9299553!35857849     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Adv 2022 ; 8 (29): eabo0171 Nephropedia Template TP {{tp|p=35857849|t=2022. Tunneling nanotubes provide a route for SARS-CoV-2 spreading |pdf=|usr=}}{{35857849}} gab.com Text Tunneling nanotubes provide a route for SARS-CoV-2 spreading JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=35857849 #FOAvip Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection represent a major issue in long coronavirus disease. How SARS-CoV-2 gains access to the brain and how infection leads to neurological symptoms are not clear because the principal means of viral entry by endocytosis, the angiotensin-converting enzyme 2 receptor, are barely detectable in the brain. We report that human neuronal cells, nonpermissive to infection through the endocytic pathway, can be infected when cocultured with permissive infected epithelial cells. SARS-CoV-2 induces the formation of tunneling nanotubes (TNTs) and exploits this route to spread to uninfected cells. In cellulo correlative fluorescence and cryo-electron tomography reveal that SARS-CoV-2 is associated with TNTs between permissive cells. Furthermore, multiple vesicular structures such as double-membrane vesicles, sites of viral replication, are observed inside TNTs between permissive and nonpermissive cells. Our data highlight a previously unknown mechanism of SARS-CoV-2 spreading, likely used as a route to invade nonpermissive cells and potentiate infection in permissive cells. Twit Text FOAVip Tunneling nanotubes provide a route for SARS-CoV-2 spreading ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=35857849 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35857849 #FOAvip English Wikipedia <ref>{{Cite pmid|35857849}}</ref> Tunneling nanotubes provide a route for SARS-CoV-2 spreading #MMPMID35857849 Pepe A; Pietropaoli S; Vos M; Barba-Spaeth G; Zurzolo C Sci Adv 2022[Jul]; 8 (29): eabo0171 PMID35857849show ga Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection represent a major issue in long coronavirus disease. How SARS-CoV-2 gains access to the brain and how infection leads to neurological symptoms are not clear because the principal means of viral entry by endocytosis, the angiotensin-converting enzyme 2 receptor, are barely detectable in the brain. We report that human neuronal cells, nonpermissive to infection through the endocytic pathway, can be infected when cocultured with permissive infected epithelial cells. SARS-CoV-2 induces the formation of tunneling nanotubes (TNTs) and exploits this route to spread to uninfected cells. In cellulo correlative fluorescence and cryo-electron tomography reveal that SARS-CoV-2 is associated with TNTs between permissive cells. Furthermore, multiple vesicular structures such as double-membrane vesicles, sites of viral replication, are observed inside TNTs between permissive and nonpermissive cells. Our data highlight a previously unknown mechanism of SARS-CoV-2 spreading, likely used as a route to invade nonpermissive cells and potentiate infection in permissive cells. äTunneling nanotubes provide a route for SARS-CoV-2 spreading (epmc).pdf DeepDyve Pubget Overpricing