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10.1126/sciimmunol.abn3127 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abn3127 35857619!9348748!35857619     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2022 ; 7 (76): eabn3127 Nephropedia Template TP {{tp|p=35857619|t=2022. SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens |pdf=|usr=}}{{35857619}} gab.com Text SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35857619 #FOAvip The baseline composition of T cells directly affects later response to pathogens, but the complexity of precursor states remains poorly defined. Here, we examined the baseline state of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cells in unexposed individuals. SARS-CoV-2-specific CD4(+) T cells were identified in prepandemic blood samples by major histocompatibility complex (MHC) class II tetramer staining and enrichment. Our data revealed a substantial number of SARS-CoV-2-specific T cells that expressed memory phenotype markers. Integrated phenotypic analyses demonstrated diverse preexisting memory states that included cells with distinct polarization features and trafficking potential to barrier tissues. T cell clones generated from tetramer-labeled cells cross-reacted with antigens from commensal bacteria in the skin and gastrointestinal tract. Direct ex vivo tetramer staining for one spike-specific population showed a similar level of cross-reactivity to sequences from endemic coronavirus and commensal bacteria. These data highlight the complexity of precursor T cell repertoire and implicate noninfectious exposures to common microbes as a key factor that shapes human preexisting immunity to SARS-CoV-2. Twit Text FOAVip SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35857619 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35857619 #FOAvip English Wikipedia <ref>{{Cite pmid|35857619}}</ref> SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens #MMPMID35857619 Bartolo L; Afroz S; Pan YG; Xu R; Williams L; Lin CF; Tanes C; Bittinger K; Friedman ES; Gimotty PA; Wu GD; Su LF Sci Immunol 2022[Oct]; 7 (76): eabn3127 PMID35857619show ga The baseline composition of T cells directly affects later response to pathogens, but the complexity of precursor states remains poorly defined. Here, we examined the baseline state of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cells in unexposed individuals. SARS-CoV-2-specific CD4(+) T cells were identified in prepandemic blood samples by major histocompatibility complex (MHC) class II tetramer staining and enrichment. Our data revealed a substantial number of SARS-CoV-2-specific T cells that expressed memory phenotype markers. Integrated phenotypic analyses demonstrated diverse preexisting memory states that included cells with distinct polarization features and trafficking potential to barrier tissues. T cell clones generated from tetramer-labeled cells cross-reacted with antigens from commensal bacteria in the skin and gastrointestinal tract. Direct ex vivo tetramer staining for one spike-specific population showed a similar level of cross-reactivity to sequences from endemic coronavirus and commensal bacteria. These data highlight the complexity of precursor T cell repertoire and implicate noninfectious exposures to common microbes as a key factor that shapes human preexisting immunity to SARS-CoV-2. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Adult[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Spike Glycoprotein, Coronavirus[MESH]SARS-CoV-2-specific T cells in unexposed adults display broad traffick(epmc).pdf DeepDyve Pubget Overpricing