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10.1016/j.bbrc.2022.07.016 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2022.07.016 35843095!9263688!35843095     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35843095&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Biochem+Biophys+Res+Commun 2022 ; 622 (?): 57-63 Nephropedia Template TP {{tp|p=35843095|t=2022. Immunization with 674-685 fragment of SARS-Cov-2 spike protein induces neuroinflammation and impairs episodic memory of mice |pdf=|usr=}}{{35843095}} gab.com Text Immunization with 674-685 fragment of SARS-Cov-2 spike protein induces neuroinflammation and impairs episodic memory of mice JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=35843095 #FOAvip COVID-19 is accompanied by strong inflammatory reaction and is often followed by long-term cognitive disorders. The fragment 674-685 of SARS-Cov-2 spike protein was shown to interact with alpha7 nicotinic acetylcholine receptor involved in regulating both inflammatory reactions and cognitive functions. Here we show that mice immunized with the peptide corresponding to 674-685 fragment of SARS-Cov-2 spike protein conjugated to hemocyanin (KLH-674-685) demonstrate decreased level of alpha7 nicotinic acetylcholine receptors, increased levels of IL-1beta and TNFalpha in the brain and impairment of episodic memory. Choline injections prevented alpha7 nicotinic receptor decline and memory loss. Mice injected with immunoglobulins obtained from the blood of (KLH-674-685)-immunized mice also demonstrated episodic memory decline. These data allow suggesting that post-COVID memory impairment in humans is related to SARS-Cov-2 spike protein-specific immune reaction. The mechanisms of such effect are being discussed. Twit Text FOAVip Immunization with 674-685 fragment of SARS-Cov-2 spike protein induces neuroinflammation and impairs episodic memory of mice ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=35843095 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35843095 #FOAvip English Wikipedia <ref>{{Cite pmid|35843095}}</ref> Immunization with 674-685 fragment of SARS-Cov-2 spike protein induces neuroinflammation and impairs episodic memory of mice #MMPMID35843095 Lykhmus O; Kalashnyk O; Koval L; Krynina O; Komisarenko S; Skok M Biochem Biophys Res Commun 2022[Sep]; 622 (?): 57-63 PMID35843095show ga COVID-19 is accompanied by strong inflammatory reaction and is often followed by long-term cognitive disorders. The fragment 674-685 of SARS-Cov-2 spike protein was shown to interact with alpha7 nicotinic acetylcholine receptor involved in regulating both inflammatory reactions and cognitive functions. Here we show that mice immunized with the peptide corresponding to 674-685 fragment of SARS-Cov-2 spike protein conjugated to hemocyanin (KLH-674-685) demonstrate decreased level of alpha7 nicotinic acetylcholine receptors, increased levels of IL-1beta and TNFalpha in the brain and impairment of episodic memory. Choline injections prevented alpha7 nicotinic receptor decline and memory loss. Mice injected with immunoglobulins obtained from the blood of (KLH-674-685)-immunized mice also demonstrated episodic memory decline. These data allow suggesting that post-COVID memory impairment in humans is related to SARS-Cov-2 spike protein-specific immune reaction. The mechanisms of such effect are being discussed. |*COVID-19[MESH] |*Memory, Episodic[MESH] |Animals[MESH] |Humans[MESH] |Immunization[MESH] |Inflammation[MESH] |Memory Disorders/etiology/metabolism[MESH] |Mice[MESH] |Neuroinflammatory Diseases[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/adverse effects/chemistry/metabolism[MESH]Immunization with 674-685 fragment of SARS-Cov-2 spike protein induces(epmc).pdf DeepDyve Pubget Overpricing