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10.1016/j.patter.2022.100562

http://scihub22266oqcxt.onion/10.1016/j.patter.2022.100562
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35818472!9259476!35818472
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suck abstract from ncbi


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pmid35818472      Patterns+(N+Y) 2022 ; 3 (9): 100562
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  • Efficient compression of SARS-CoV-2 genome data using Nucleotide Archival Format #MMPMID35818472
  • Kryukov K; Jin L; Nakagawa S
  • Patterns (N Y) 2022[Sep]; 3 (9): 100562 PMID35818472show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome data are essential for epidemiology, vaccine development, and tracking emerging variants. Millions of SARS-CoV-2 genomes have been sequenced during the pandemic. However, downloading SARS-CoV-2 genomes from databases is slow and unreliable, largely due to suboptimal choice of compression method. We evaluated the available compressors and found that Nucleotide Archival Format (NAF) would provide a drastic improvement compared with current methods. For Global Initiative on Sharing Avian Flu Data's (GISAID) pre-compressed datasets, NAF would increase efficiency 52.2 times for gzip-compressed data and 3.7 times for xz-compressed data. For DNA DataBank of Japan (DDBJ), NAF would improve throughput 40 times for gzip-compressed data. For GenBank and European Nucleotide Archive (ENA), NAF would accelerate data distribution by a factor of 29.3 times compared with uncompressed FASTA. This article provides a tutorial for installing and using NAF. Offering a NAF download option in sequence databases would provide a significant saving of time, bandwidth, and disk space and accelerate biological and medical research worldwide.
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