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10.1016/j.ijid.2022.07.013

http://scihub22266oqcxt.onion/10.1016/j.ijid.2022.07.013
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35811081!9262656!35811081
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suck abstract from ncbi


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pmid35811081      Int+J+Infect+Dis 2022 ; 122 (ä): 576-584
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  • COVID-19 serum can be cross-reactive and neutralizing against the dengue virus, as observed by the dengue virus neutralization test #MMPMID35811081
  • Nath H; Mallick A; Roy S; Kayal T; Ranjan S; Sengupta S; Sukla S; Biswas S
  • Int J Infect Dis 2022[Sep]; 122 (ä): 576-584 PMID35811081show ga
  • OBJECTIVES: Observing the serological cross-reactivity between SARS-CoV-2 and dengue virus (DV), we aimed to elucidate its effect on dengue serodiagnosis and infectivity in a highly dengue-endemic city in India. METHODS: A total of 52 COVID-19 (reverse transcription-polymerase chain reaction [RT-PCR] positive) serum samples were tested in rapid lateral flow immunoassays and DV immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) to detect DV or SARS-CoV-2 IgG/immunoglobulin M. The COVID-19 antibody (Ab) positive samples were subjected to a virus neutralization test (Huh7 cells) using DV type 1 (DV1) clinical isolate. RESULTS: Most (93%) of the SARS-CoV-2 Ab-positive serum samples cross-reacted with DV in rapid or ELISA tests. All were DV RNA and nonstructural protein 1 (NS1) antigen-negative. COVID-19 serum samples that were DV cross-reactive neutralized DV1. Of these, 57% had no evidence of DV pre-exposure (DV NS1 Ab-negative). The computational study also supported potential interactions between SARS-CoV-2 Ab and DV1. CONCLUSION: DV serodiagnosis will be inconclusive in areas co-endemic for both viruses. The COVID-19 pandemic appears to impart a protective response against DV in DV-endemic populations.
  • |*COVID-19/diagnosis[MESH]
  • |*Dengue[MESH]
  • |*Dengue Virus[MESH]
  • |Antibodies, Viral[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G[MESH]
  • |Immunoglobulin M[MESH]
  • |Neutralization Tests[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2[MESH]
  • |Sensitivity and Specificity[MESH]


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