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10.3390/cells11131982 http://scihub22266oqcxt.onion/10.3390/cells11131982 35805067!9265820!35805067     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2022 ; 11 (13): ä Nephropedia Template TP {{tp|p=35805067|t=2022. The Possible Role of Glucose-6-Phosphate Dehydrogenase in the SARS-CoV-2 Infection |pdf=|usr=}}{{35805067}} gab.com Text The Possible Role of Glucose-6-Phosphate Dehydrogenase in the SARS-CoV-2 Infection JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=35805067 #FOAvip Glucose-6-phosphate dehydrogenase (G6PD) is the second rate-limiting enzyme of the pentose phosphate pathway. This enzyme is present in the cytoplasm of all mammalian cells, and its activity is essential for an adequate functioning of the antioxidant system and for the response of innate immunity. It is responsible for the production of nicotinamide adenine dinucleotide phosphate (NADPH), the first redox equivalent, in the pentose phosphate pathway. Viral infections such as SARS-CoV-2 may induce the Warburg effect with an increase in anaerobic glycolysis and production of lactate. This condition ensures the success of viral replication and production of the virion. Therefore, the activity of G6PD may be increased in COVID-19 patients raising the level of the NADPH, which is needed for the enzymatic and non-enzymatic antioxidant systems that counteract the oxidative stress caused by the cytokine storm. G6PD deficiency affects approximately 350-400 million people worldwide; therefore, it is one of the most prevalent diseases related to enzymatic deficiency worldwide. In G6PD-deficient patients exposed to SARS-CoV-2, the amount of NADPH is reduced, increasing the susceptibility for viral infection. There is loss of the redox homeostasis in them, resulting in severe pneumonia and fatal outcomes. Twit Text FOAVip The Possible Role of Glucose-6-Phosphate Dehydrogenase in the SARS-CoV-2 Infection ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=35805067 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35805067 #FOAvip English Wikipedia <ref>{{Cite pmid|35805067}}</ref> The Possible Role of Glucose-6-Phosphate Dehydrogenase in the SARS-CoV-2 Infection #MMPMID35805067 Perez-Torres I; Soto ME; Guarner-Lans V; Manzano-Pech L; Soria-Castro E Cells 2022[Jun]; 11 (13): ä PMID35805067show ga Glucose-6-phosphate dehydrogenase (G6PD) is the second rate-limiting enzyme of the pentose phosphate pathway. This enzyme is present in the cytoplasm of all mammalian cells, and its activity is essential for an adequate functioning of the antioxidant system and for the response of innate immunity. It is responsible for the production of nicotinamide adenine dinucleotide phosphate (NADPH), the first redox equivalent, in the pentose phosphate pathway. Viral infections such as SARS-CoV-2 may induce the Warburg effect with an increase in anaerobic glycolysis and production of lactate. This condition ensures the success of viral replication and production of the virion. Therefore, the activity of G6PD may be increased in COVID-19 patients raising the level of the NADPH, which is needed for the enzymatic and non-enzymatic antioxidant systems that counteract the oxidative stress caused by the cytokine storm. G6PD deficiency affects approximately 350-400 million people worldwide; therefore, it is one of the most prevalent diseases related to enzymatic deficiency worldwide. In G6PD-deficient patients exposed to SARS-CoV-2, the amount of NADPH is reduced, increasing the susceptibility for viral infection. There is loss of the redox homeostasis in them, resulting in severe pneumonia and fatal outcomes. |*COVID-19[MESH] |*Glucosephosphate Dehydrogenase/metabolism[MESH] |Animals[MESH] |Antioxidants[MESH] |Humans[MESH] |Mammals/metabolism[MESH] |NADP/metabolism[MESH]The Possible Role of Glucose-6-Phosphate Dehydrogenase in the SARS-CoV(epmc).pdf DeepDyve Pubget Overpricing