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10.1007/s00018-022-04417-9 http://scihub22266oqcxt.onion/10.1007/s00018-022-04417-9 35773608!10428948!35773608     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35773608&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cell+Mol+Life+Sci 2022 ; 79 (7): 389 Nephropedia Template TP {{tp|p=35773608|t=2022. EWI2 prevents EGFR from clustering and endocytosis to reduce tumor cell movement and proliferation |pdf=|usr=}}{{35773608}} gab.com Text EWI2 prevents EGFR from clustering and endocytosis to reduce tumor cell movement and proliferation JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=35773608 #FOAvip EWI2 is a transmembrane immunoglobulin superfamily (IgSF) protein that physically associates with tetraspanins and integrins. It inhibits cancer cells by influencing the interactions among membrane molecules including the tetraspanins and integrins. The present study revealed that, upon EWI2 silencing or ablation, the elevated movement and proliferation of cancer cells in vitro and increased cancer metastatic potential and malignancy in vivo are associated with (i) increases in clustering, endocytosis, and then activation of EGFR and (ii) enhancement of Erk MAP kinase signaling. These changes in signaling make cancer cells (i) undergo partial epithelial-to-mesenchymal (EMT) for more tumor progression and (ii) proliferate faster for better tumor formation. Inhibition of EGFR or Erk kinase can abrogate the cancer cell phenotypes resulting from EWI2 removal. Thus, to inhibit cancer cells, EWI2 prevents EGFR from clustering and endocytosis to restrain its activation and signaling. Twit Text FOAVip EWI2 prevents EGFR from clustering and endocytosis to reduce tumor cell movement and proliferation ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=35773608 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35773608 #FOAvip English Wikipedia <ref>{{Cite pmid|35773608}}</ref> EWI2 prevents EGFR from clustering and endocytosis to reduce tumor cell movement and proliferation #MMPMID35773608 Fu C; Wang J; Pallikkuth S; Ding Y; Chen J; Wren JD; Yang Y; Wong KK; Kameyama H; Jayaraman M; Munshi A; Tanaka T; Lidke KA; Zhang XA Cell Mol Life Sci 2022[Jun]; 79 (7): 389 PMID35773608show ga EWI2 is a transmembrane immunoglobulin superfamily (IgSF) protein that physically associates with tetraspanins and integrins. It inhibits cancer cells by influencing the interactions among membrane molecules including the tetraspanins and integrins. The present study revealed that, upon EWI2 silencing or ablation, the elevated movement and proliferation of cancer cells in vitro and increased cancer metastatic potential and malignancy in vivo are associated with (i) increases in clustering, endocytosis, and then activation of EGFR and (ii) enhancement of Erk MAP kinase signaling. These changes in signaling make cancer cells (i) undergo partial epithelial-to-mesenchymal (EMT) for more tumor progression and (ii) proliferate faster for better tumor formation. Inhibition of EGFR or Erk kinase can abrogate the cancer cell phenotypes resulting from EWI2 removal. Thus, to inhibit cancer cells, EWI2 prevents EGFR from clustering and endocytosis to restrain its activation and signaling. |*Antigens, CD/metabolism[MESH] |*Endocytosis[MESH] |*ErbB Receptors/genetics/metabolism[MESH] |*Membrane Proteins/deficiency/genetics/metabolism[MESH] |*Neoplasms/genetics/metabolism/pathology[MESH] |Cell Line, Tumor[MESH] |Cell Movement/physiology[MESH] |Cell Proliferation/physiology[MESH] |Epithelial-Mesenchymal Transition[MESH] |Humans[MESH]EWI2 prevents EGFR from clustering and endocytosis to reduce tumor cel(epmc).pdf DeepDyve Pubget Overpricing