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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 NPJ+Digit+Med 2022 ; 5 (1): 83 Nephropedia Template TP
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The IDentif AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens #MMPMID35773329
Blasiak A; Truong ATL; Remus A; Hooi L; Seah SGK; Wang P; Chye H; Lim APC; Ng KT; Teo ST; Tan YJ; Allen DM; Chai LYA; Chng WJ; Lin RTP; Lye DCB; Wong JE; Tan GG; Chan CEZ; Chow EK; Ho D
NPJ Digit Med 2022[Jun]; 5 (1): 83 PMID35773329show ga
IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a SARS-CoV-2 live virus and Vero E6 assay with a quadratic optimization workflow. A starting pool of 12 candidate drugs developed in collaboration with a community of infectious disease clinicians was first narrowed down to a six-drug pool and then interrogated in 50 combination regimens at three dosing levels per drug, representing 729 possible combinations. IDentif.AI-x revealed EIDD-1931 to be a strong candidate upon which multiple drug combinations can be derived, and pinpointed a number of clinically actionable drug interactions, which were further reconfirmed in SARS-CoV-2 variants B.1.351 (Beta) and B.1.617.2 (Delta). IDentif.AI-x prioritized promising drug combinations for clinical translation and can be immediately adjusted and re-executed with a new pool of promising therapies in an actionable path towards rapidly optimizing combination therapy following pandemic emergence.