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10.1016/j.transproceed.2022.05.007

http://scihub22266oqcxt.onion/10.1016/j.transproceed.2022.05.007
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35773083!9149239!35773083
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suck abstract from ncbi


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pmid35773083      Transplant+Proc 2022 ; 54 (6): 1564-1568
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  • Atypical Unilateral SARS-CoV-2 Pneumonia in a Single Lung Re-Transplanted Patient: A Case Report #MMPMID35773083
  • Furstenberger M; Gallais F; Freudenberger S; Kessler R; Chenard MP; Renaud-Picard B
  • Transplant Proc 2022[Jul]; 54 (6): 1564-1568 PMID35773083show ga
  • BACKGROUND: Since December 2019, the SARS-CoV-2 pandemic significantly has impacted the medical community. When infected with SARS-CoV-2, most of the patients developed bilateral pneumonia. We have herein presented the atypical case of a patient who developed unilateral SARS-CoV-2 pneumonia, affecting only the second lung allograft re-transplanted (re-LTX). CASE PRESENTATION: A SARS-CoV-2 infection occurred in a 2-dose vaccinated patient with LTx with a history of second unilateral lung transplantation performed after an end-stage bronchiolitis obliterans syndrome. The first symptoms started with a flu-like syndrome, and the patient's clinical condition worsened with nonsevere acute respiratory failure requiring conventional oxygen therapy. Treatment consisted in administrating specific anti-SARS-CoV-2 monoclonal antibodies along with probabilistic antibiotherapy, anticoagulation, and steroids. On day 7, the patient was discharged from hospital. We aimed to assess this atypical unilateral pneumonia based on different explorations. A ventilation scintigraphy showed a severe ventilation decrease owing to end-stage bronchiolitis obliterans syndrome within the left first allograft, which may be associated with asymmetrical virus diffusion between the 2 lungs. We did not identify any other relevant differences with respect to the 2 donors' clinical characteristics. Using specific immunohistochemistry staining against angiotensin converting enzyme-2 receptor, the main known receptor for SARS-CoV-2 binding on airway epithelial cells, no staining difference was observed between the 2 lung biopsies that were collected at re-LTx from each lung. CONCLUSIONS: With the present case report, we aimed to highlight how this kind of unusual presentation may be caused by the difference of ventilation between the 2 lungs.
  • |*Bronchiolitis Obliterans/pathology[MESH]
  • |*COVID-19[MESH]
  • |*Influenza, Human[MESH]
  • |*Lung Diseases, Interstitial[MESH]
  • |*Pneumonia, Mycoplasma[MESH]
  • |Antibodies, Monoclonal[MESH]
  • |Antibodies, Viral[MESH]
  • |Anticoagulants[MESH]
  • |Humans[MESH]
  • |Lung/diagnostic imaging/pathology[MESH]
  • |Oxygen[MESH]
  • |Peptidyl-Dipeptidase A[MESH]


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