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10.1124/jpet.122.001209 http://scihub22266oqcxt.onion/10.1124/jpet.122.001209 35772782!9827505!35772782     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pharmacol+Exp+Ther 2023 ; 384 (1): 109-115 Nephropedia Template TP {{tp|p=35772782|t=2023. Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19 |pdf=|usr=}}{{35772782}} gab.com Text Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19 JO: J Pharmacol Exp Ther http://www.kidney.de/pget.php?&tw=1&pmid=35772782 #FOAvip We hypothesized that exosomal microRNAs could be implied in the pathogenesis of thromboembolic complications in coronavirus disease 2019 (COVID-19). We isolated circulating exosomes from patients with COVID-19, and then we divided our population in two arms based on the D-dimer level on hospital admission. We observed that exosomal miR-145 and miR-885 significantly correlate with D-dimer levels. Moreover, we demonstrate that human endothelial cells express the main cofactors needed for the internalization of the "Severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2), including angiotensin converting enzyme 2, transmembrane protease serine 2, and CD-147. Interestingly, human endothelial cells treated with serum from COVID-19 patients release significantly less miR-145 and miR-885, exhibit increased apoptosis, and display significantly impaired angiogenetic properties compared with cells treated with non-COVID-19 serum. Taken together, our data indicate that exosomal miR-145 and miR-885 are essential in modulating thromboembolic events in COVID-19. SIGNIFICANCE STATEMENT: This work demonstrates for the first time that two specific microRNAs (namely miR-145 and miR-885) contained in circulating exosomes are functionally involved in thromboembolic events in COVID-19. These findings are especially relevant to the general audience when considering the emerging prominence of post-acute sequelae of COVID-19 systemic manifestations known as Long COVID. Twit Text FOAVip Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19 ????J Pharmacol Exp Ther http://www.kidney.de/pget.php?&tw=1&pmid=35772782 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35772782 #FOAvip English Wikipedia <ref>{{Cite pmid|35772782}}</ref> Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19 #MMPMID35772782 Gambardella J; Kansakar U; Sardu C; Messina V; Jankauskas SS; Marfella R; Maggi P; Wang X; Mone P; Paolisso G; Sorriento D; Santulli G J Pharmacol Exp Ther 2023[Jan]; 384 (1): 109-115 PMID35772782show ga We hypothesized that exosomal microRNAs could be implied in the pathogenesis of thromboembolic complications in coronavirus disease 2019 (COVID-19). We isolated circulating exosomes from patients with COVID-19, and then we divided our population in two arms based on the D-dimer level on hospital admission. We observed that exosomal miR-145 and miR-885 significantly correlate with D-dimer levels. Moreover, we demonstrate that human endothelial cells express the main cofactors needed for the internalization of the "Severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2), including angiotensin converting enzyme 2, transmembrane protease serine 2, and CD-147. Interestingly, human endothelial cells treated with serum from COVID-19 patients release significantly less miR-145 and miR-885, exhibit increased apoptosis, and display significantly impaired angiogenetic properties compared with cells treated with non-COVID-19 serum. Taken together, our data indicate that exosomal miR-145 and miR-885 are essential in modulating thromboembolic events in COVID-19. SIGNIFICANCE STATEMENT: This work demonstrates for the first time that two specific microRNAs (namely miR-145 and miR-885) contained in circulating exosomes are functionally involved in thromboembolic events in COVID-19. These findings are especially relevant to the general audience when considering the emerging prominence of post-acute sequelae of COVID-19 systemic manifestations known as Long COVID. |*COVID-19/complications[MESH] |*Exosomes/metabolism[MESH] |*MicroRNAs/genetics/metabolism[MESH] |*Post-Acute COVID-19 Syndrome/genetics/metabolism[MESH] |*Thrombosis/genetics/metabolism/virology[MESH] |Endothelial Cells[MESH] |Humans[MESH]Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing