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10.1002/jmv.27965 http://scihub22266oqcxt.onion/10.1002/jmv.27965 35765167!9350412!35765167     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35765167.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Med+Virol 2022 ; 94 (11): 5174-5188 Nephropedia Template TP {{tp|p=35765167|t=2022. SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagy |pdf=|usr=}}{{35765167}} gab.com Text SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagy JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=35765167 #FOAvip A characteristic feature of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is the dysregulated immune response with impaired type I and III interferon (IFN) expression and an overwhelming inflammatory cytokine storm. RIG-I-like receptors (RLRs) and cGAS-STING signaling pathways are responsible for sensing viral infection and inducing IFN production to combat invading viruses. Multiple proteins of SARS-CoV-2 have been reported to modulate the RLR signaling pathways to achieve immune evasion. Although SARS-CoV-2 infection also activates the cGAS-STING signaling by stimulating micronuclei formation during the process of syncytia, whether SARS-CoV-2 modulates the cGAS-STING pathway requires further investigation. Here, we screened 29 SARS-CoV-2-encoded viral proteins to explore the viral proteins that affect the cGAS-STING signaling pathway and found that SARS-CoV-2 open reading frame 10 (ORF10) targets STING to antagonize IFN activation. Overexpression of ORF10 inhibits cGAS-STING-induced interferon regulatory factor 3 phosphorylation, translocation, and subsequent IFN induction. Mechanistically, ORF10 interacts with STING, attenuates the STING-TBK1 association, and impairs STING oligomerization and aggregation and STING-mediated autophagy; ORF10 also prevents the endoplasmic reticulum (ER)-to-Golgi trafficking of STING by anchoring STING in the ER. Taken together, these findings suggest that SARS-CoV-2 ORF10 impairs the cGAS-STING signaling by blocking the translocation of STING and the interaction between STING and TBK1 to antagonize innate antiviral immunity. Twit Text FOAVip SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagy ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=35765167 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35765167 #FOAvip English Wikipedia <ref>{{Cite pmid|35765167}}</ref> SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagy #MMPMID35765167 Han L; Zheng Y; Deng J; Nan ML; Xiao Y; Zhuang MW; Zhang J; Wang W; Gao C; Wang PH J Med Virol 2022[Nov]; 94 (11): 5174-5188 PMID35765167show ga A characteristic feature of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is the dysregulated immune response with impaired type I and III interferon (IFN) expression and an overwhelming inflammatory cytokine storm. RIG-I-like receptors (RLRs) and cGAS-STING signaling pathways are responsible for sensing viral infection and inducing IFN production to combat invading viruses. Multiple proteins of SARS-CoV-2 have been reported to modulate the RLR signaling pathways to achieve immune evasion. Although SARS-CoV-2 infection also activates the cGAS-STING signaling by stimulating micronuclei formation during the process of syncytia, whether SARS-CoV-2 modulates the cGAS-STING pathway requires further investigation. Here, we screened 29 SARS-CoV-2-encoded viral proteins to explore the viral proteins that affect the cGAS-STING signaling pathway and found that SARS-CoV-2 open reading frame 10 (ORF10) targets STING to antagonize IFN activation. Overexpression of ORF10 inhibits cGAS-STING-induced interferon regulatory factor 3 phosphorylation, translocation, and subsequent IFN induction. Mechanistically, ORF10 interacts with STING, attenuates the STING-TBK1 association, and impairs STING oligomerization and aggregation and STING-mediated autophagy; ORF10 also prevents the endoplasmic reticulum (ER)-to-Golgi trafficking of STING by anchoring STING in the ER. Taken together, these findings suggest that SARS-CoV-2 ORF10 impairs the cGAS-STING signaling by blocking the translocation of STING and the interaction between STING and TBK1 to antagonize innate antiviral immunity. |*COVID-19[MESH] |*Interferon Type I/genetics[MESH] |Autophagy[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Interferons[MESH] |Membrane Proteins/genetics/metabolism[MESH] |Nucleotidyltransferases/genetics[MESH] |Open Reading Frames[MESH] |Protein Serine-Threonine Kinases/genetics[MESH] |SARS-CoV-2[MESH]SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and(epmc).pdf DeepDyve Pubget Overpricing