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10.1073/pnas.2200109119 http://scihub22266oqcxt.onion/10.1073/pnas.2200109119 35763573!9271203!35763573     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2022 ; 119 (27): e2200109119 Nephropedia Template TP {{tp|p=35763573|t=2022. The dynamics of SARS-CoV-2 infectivity with changes in aerosol microenvironment |pdf=|usr=}}{{35763573}} gab.com Text The dynamics of SARS-CoV-2 infectivity with changes in aerosol microenvironment JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=35763573 #FOAvip Understanding the factors that influence the airborne survival of viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in aerosols is important for identifying routes of transmission and the value of various mitigation strategies for preventing transmission. We present measurements of the stability of SARS-CoV-2 in aerosol droplets ( approximately 5 to 10 microm equilibrated radius) over timescales spanning 5 s to 20 min using an instrument to probe survival in a small population of droplets (typically 5 to 10) containing approximately 1 virus/droplet. Measurements of airborne infectivity change are coupled with a detailed physicochemical analysis of the airborne droplets containing the virus. A decrease in infectivity to approximately 10% of the starting value was observable for SARS-CoV-2 over 20 min, with a large proportion of the loss occurring within the first 5 min after aerosolization. The initial rate of infectivity loss was found to correlate with physical transformation of the equilibrating droplet; salts within the droplets crystallize at relative humidities (RHs) below 50%, leading to a near-instant loss of infectivity in 50 to 60% of the virus. However, at 90% RH, the droplet remains homogenous and aqueous, and the viral stability is sustained for the first 2 min, beyond which it decays to only 10% remaining infectious after 10 min. The loss of infectivity at high RH is consistent with an elevation in the pH of the droplets, caused by volatilization of CO(2) from bicarbonate buffer within the droplet. Four different variants of SARS-CoV-2 were compared and found to have a similar degree of airborne stability at both high and low RH. Twit Text FOAVip The dynamics of SARS-CoV-2 infectivity with changes in aerosol microenvironment ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=35763573 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35763573 #FOAvip English Wikipedia <ref>{{Cite pmid|35763573}}</ref> The dynamics of SARS-CoV-2 infectivity with changes in aerosol microenvironment #MMPMID35763573 Oswin HP; Haddrell AE; Otero-Fernandez M; Mann JFS; Cogan TA; Hilditch TG; Tian J; Hardy DA; Hill DJ; Finn A; Davidson AD; Reid JP Proc Natl Acad Sci U S A 2022[Jul]; 119 (27): e2200109119 PMID35763573show ga Understanding the factors that influence the airborne survival of viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in aerosols is important for identifying routes of transmission and the value of various mitigation strategies for preventing transmission. We present measurements of the stability of SARS-CoV-2 in aerosol droplets ( approximately 5 to 10 microm equilibrated radius) over timescales spanning 5 s to 20 min using an instrument to probe survival in a small population of droplets (typically 5 to 10) containing approximately 1 virus/droplet. Measurements of airborne infectivity change are coupled with a detailed physicochemical analysis of the airborne droplets containing the virus. A decrease in infectivity to approximately 10% of the starting value was observable for SARS-CoV-2 over 20 min, with a large proportion of the loss occurring within the first 5 min after aerosolization. The initial rate of infectivity loss was found to correlate with physical transformation of the equilibrating droplet; salts within the droplets crystallize at relative humidities (RHs) below 50%, leading to a near-instant loss of infectivity in 50 to 60% of the virus. However, at 90% RH, the droplet remains homogenous and aqueous, and the viral stability is sustained for the first 2 min, beyond which it decays to only 10% remaining infectious after 10 min. The loss of infectivity at high RH is consistent with an elevation in the pH of the droplets, caused by volatilization of CO(2) from bicarbonate buffer within the droplet. Four different variants of SARS-CoV-2 were compared and found to have a similar degree of airborne stability at both high and low RH. |*Aerosolized Particles and Droplets/chemistry/isolation & purification[MESH] |*COVID-19/transmission[MESH] |*SARS-CoV-2/isolation & purification/pathogenicity[MESH] |Humans[MESH] |Humidity[MESH]The dynamics of SARS-CoV-2 infectivity with changes in aerosol microen(epmc).pdf DeepDyve Pubget Overpricing