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10.2174/1389203723666220628114928 http://scihub22266oqcxt.onion/10.2174/1389203723666220628114928 35762551!ä!35762551 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Protein+Pept+Sci 2022 ; 23 (5): 321-334 Nephropedia Template TP {{tp|p=35762551|t=2022. Targeting and Modulation of the Natriuretic Peptide System in Covid-19: A Single or Double-Edged Effect?|pdf=|usr=}}{{35762551}} gab.com Text Targeting and Modulation of the Natriuretic Peptide System in Covid-19: A Single or Double-Edged Effect JO: Curr Protein Pept Sci http://www.kidney.de/pget.php?&tw=1&pmid=35762551 #FOAvip Natriuretic peptide system (NPS) is a group of peptide hormones or paracrine factors, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and natriuretic peptide precursor C (NPC), that are structurally related. The physiological effects of NPS include natriuresis, increased glomerular filtration rate, inhibition release of renin, vasopressin, and aldosterone, sympathetic inhibition, vasodilatations, and prevents cardiac hypertrophy and remodeling. ANP has immunological effects, as it is produced locally from immune cells; it regulates innate and adaptive immune responses. Metabolism and degradation of ANP are achieved by neutral endopeptidase (NEP), also known as neprilysin. Coronavirus disease 2019 (Covid-19) pandemic may lead to acute lung injury (ALI) and/or respiratory distress syndrome (ARDS). The underlying causes of inflammatory and immunological disorders in patients with severe Covid-19 are connected to the immune over-stimulation with the subsequent release of pro-inflammatory cytokines. Covid-19 severity is linked with high ANP serum levels regardless of acute cardiac injury. Inflammatory stimuli appear to be linked with the release of NPs, which anti-inflammatory effects prevent the development of ALI/ARDS in Covid-19. Therefore, neprilysin inhibitors like sacubitril increase endogenous NPs and may reduce the risk of ALI in Covid-19 due to the potentiation of endogenous anti-inflammatory effects of NPs. However, sacubitril increases gastrin-releasing peptide, cathepsin G and release of pro-inflammatory cytokines that are inactivated by neprilysin. In conclusion, NPs and neprilysin have cardio-pulmonary protective effects against Covid-19-induced ALI/ARDS. Neprilysin inhibitor sacubitril has dual protective and harmful effects regarding metabolizing vasoactive peptides by neprilysin. These findings require potential reevaluation of the effect of neprilysin inhibitors in managing Covid-19. Twit Text FOAVip Targeting and Modulation of the Natriuretic Peptide System in Covid-19: A Single or Double-Edged Effect ????Curr Protein Pept Sci http://www.kidney.de/pget.php?&tw=1&pmid=35762551 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35762551 #FOAvip English Wikipedia <ref>{{Cite pmid|35762551}}</ref> Targeting and Modulation of the Natriuretic Peptide System in Covid-19: A Single or Double-Edged Effect? #MMPMID35762551 Al-Kuraishy HM; Al-Gareeb AI; Alexiou A; Batiha GE Curr Protein Pept Sci 2022[]; 23 (5): 321-334 PMID35762551show ga Natriuretic peptide system (NPS) is a group of peptide hormones or paracrine factors, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and natriuretic peptide precursor C (NPC), that are structurally related. The physiological effects of NPS include natriuresis, increased glomerular filtration rate, inhibition release of renin, vasopressin, and aldosterone, sympathetic inhibition, vasodilatations, and prevents cardiac hypertrophy and remodeling. ANP has immunological effects, as it is produced locally from immune cells; it regulates innate and adaptive immune responses. Metabolism and degradation of ANP are achieved by neutral endopeptidase (NEP), also known as neprilysin. Coronavirus disease 2019 (Covid-19) pandemic may lead to acute lung injury (ALI) and/or respiratory distress syndrome (ARDS). The underlying causes of inflammatory and immunological disorders in patients with severe Covid-19 are connected to the immune over-stimulation with the subsequent release of pro-inflammatory cytokines. Covid-19 severity is linked with high ANP serum levels regardless of acute cardiac injury. Inflammatory stimuli appear to be linked with the release of NPs, which anti-inflammatory effects prevent the development of ALI/ARDS in Covid-19. Therefore, neprilysin inhibitors like sacubitril increase endogenous NPs and may reduce the risk of ALI in Covid-19 due to the potentiation of endogenous anti-inflammatory effects of NPs. However, sacubitril increases gastrin-releasing peptide, cathepsin G and release of pro-inflammatory cytokines that are inactivated by neprilysin. In conclusion, NPs and neprilysin have cardio-pulmonary protective effects against Covid-19-induced ALI/ARDS. Neprilysin inhibitor sacubitril has dual protective and harmful effects regarding metabolizing vasoactive peptides by neprilysin. These findings require potential reevaluation of the effect of neprilysin inhibitors in managing Covid-19. |*COVID-19 Drug Treatment[MESH] |*Heart Failure/drug therapy[MESH] |*Respiratory Distress Syndrome[MESH] |Aldosterone[MESH] |Aminobutyrates[MESH] |Anti-Inflammatory Agents[MESH] |Atrial Natriuretic Factor/metabolism/therapeutic use[MESH] |Biphenyl Compounds[MESH] |Cathepsin G[MESH] |Cytokines[MESH] |Gastrin-Releasing Peptide/therapeutic use[MESH] |Humans[MESH] |Natriuretic Peptide, Brain/metabolism/therapeutic use[MESH] |Natriuretic Peptides[MESH] |Neprilysin/metabolism/therapeutic use[MESH] |Renin/therapeutic use[MESH] |Tetrazoles/pharmacology/therapeutic use[MESH]Targeting and Modulation of the Natriuretic Peptide System in Covid-19(epmc).pdf DeepDyve Pubget Overpricing