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10.3390/v14061185 http://scihub22266oqcxt.onion/10.3390/v14061185 35746657!9227269!35746657     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35746657&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35746657.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Viruses 2022 ; 14 (6): ä Nephropedia Template TP {{tp|p=35746657|t=2022. Carriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatening COVID-19 |pdf=|usr=}}{{35746657}} gab.com Text Carriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatening COVID-19 JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35746657 #FOAvip Thrombosis of small and large vessels is reported as a key player in COVID-19 severity. However, host genetic determinants of this susceptibility are still unclear. Congenital Thrombotic Thrombocytopenic Purpura is a severe autosomal recessive disorder characterized by uncleaved ultra-large vWF and thrombotic microangiopathy, frequently triggered by infections. Carriers are reported to be asymptomatic. Exome analysis of about 3000 SARS-CoV-2 infected subjects of different severities, belonging to the GEN-COVID cohort, revealed the specific role of vWF cleaving enzyme ADAMTS13 (A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13). We report here that ultra-rare variants in a heterozygous state lead to a rare form of COVID-19 characterized by hyper-inflammation signs, which segregates in families as an autosomal dominant disorder conditioned by SARS-CoV-2 infection, sex, and age. This has clinical relevance due to the availability of drugs such as Caplacizumab, which inhibits vWF-platelet interaction, and Crizanlizumab, which, by inhibiting P-selectin binding to its ligands, prevents leukocyte recruitment and platelet aggregation at the site of vascular damage. Twit Text FOAVip Carriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatening COVID-19 ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35746657 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35746657 #FOAvip English Wikipedia <ref>{{Cite pmid|35746657}}</ref> Carriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatening COVID-19 #MMPMID35746657 Zguro K; Baldassarri M; Fava F; Beligni G; Daga S; Leoncini R; Galasso L; Cirianni M; Rusconi S; Siano M; Francisci D; Schiaroli E; Luchi S; Morelli G; Martinelli E; Girardis M; Busani S; Parisi SG; Panese S; Piscopo C; Capasso M; Tacconi D; Spertilli Raffaelli C; Giliberti A; Gori G; Katsikis PD; Lorubbio M; Calzoni P; Ognibene A; Bocchia M; Tozzi M; Bucalossi A; Marotta G; Furini S; Gen-Covid Multicenter Study; Renieri A; Fallerini C Viruses 2022[May]; 14 (6): ä PMID35746657show ga Thrombosis of small and large vessels is reported as a key player in COVID-19 severity. However, host genetic determinants of this susceptibility are still unclear. Congenital Thrombotic Thrombocytopenic Purpura is a severe autosomal recessive disorder characterized by uncleaved ultra-large vWF and thrombotic microangiopathy, frequently triggered by infections. Carriers are reported to be asymptomatic. Exome analysis of about 3000 SARS-CoV-2 infected subjects of different severities, belonging to the GEN-COVID cohort, revealed the specific role of vWF cleaving enzyme ADAMTS13 (A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13). We report here that ultra-rare variants in a heterozygous state lead to a rare form of COVID-19 characterized by hyper-inflammation signs, which segregates in families as an autosomal dominant disorder conditioned by SARS-CoV-2 infection, sex, and age. This has clinical relevance due to the availability of drugs such as Caplacizumab, which inhibits vWF-platelet interaction, and Crizanlizumab, which, by inhibiting P-selectin binding to its ligands, prevents leukocyte recruitment and platelet aggregation at the site of vascular damage. |*COVID-19/genetics[MESH] |*Purpura, Thrombotic Thrombocytopenic/diagnosis/genetics[MESH] |ADAM Proteins/genetics/metabolism[MESH] |ADAMTS13 Protein/genetics[MESH] |Humans[MESH] |SARS-CoV-2/pathogenicity[MESH]Carriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatenin(epmc).pdf DeepDyve Pubget Overpricing