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10.3390/v14061141 http://scihub22266oqcxt.onion/10.3390/v14061141 35746613!9228376!35746613     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2022 ; 14 (6): ä Nephropedia Template TP {{tp|p=35746613|t=2022. Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein |pdf=|usr=}}{{35746613}} gab.com Text Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35746613 #FOAvip COVID-19 caused by SARS-CoV-2 is continuing to spread around the world and drastically affect our daily life. New strains appear, and the severity of the course of the disease itself seems to be decreasing, but even people who have been ill on an outpatient basis suffer post-COVID consequences. Partly, it is associated with the autoimmune reactions, so debates about the development of new vaccines and the need for vaccination/revaccination continue. In this study we performed an analysis of the antibody response of patients with COVID-19 to linear and conformational epitopes of viral proteins using ELISA, chip array and western blot with analysis of correlations between antibody titer, disease severity, and complications. We have shown that the presence of IgG antibodies to the nucleoprotein can deteriorate the course of the disease, induce multiple direct COVID-19 symptoms, and contribute to long-term post-covid symptoms. We analyzed the cross reactivity of antibodies to SARS-CoV-2 with own human proteins and showed that antibodies to the nucleocapsid protein can bind to human proteins. In accordance with the possibility of HLA presentation, the main possible targets of the autoantibodies were identified. People with HLA alleles A01:01; A26:01; B39:01; B15:01 are most susceptible to the development of autoimmune processes after COVID-19. Twit Text FOAVip Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35746613 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35746613 #FOAvip English Wikipedia <ref>{{Cite pmid|35746613}}</ref> Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein #MMPMID35746613 Matyushkina D; Shokina V; Tikhonova P; Manuvera V; Shirokov D; Kharlampieva D; Lazarev V; Varizhuk A; Vedekhina T; Pavlenko A; Penkin L; Arapidi G; Pavlov K; Pushkar D; Kolontarev K; Rumyantsev A; Rumyantsev S; Rychkova L; Govorun V Viruses 2022[May]; 14 (6): ä PMID35746613show ga COVID-19 caused by SARS-CoV-2 is continuing to spread around the world and drastically affect our daily life. New strains appear, and the severity of the course of the disease itself seems to be decreasing, but even people who have been ill on an outpatient basis suffer post-COVID consequences. Partly, it is associated with the autoimmune reactions, so debates about the development of new vaccines and the need for vaccination/revaccination continue. In this study we performed an analysis of the antibody response of patients with COVID-19 to linear and conformational epitopes of viral proteins using ELISA, chip array and western blot with analysis of correlations between antibody titer, disease severity, and complications. We have shown that the presence of IgG antibodies to the nucleoprotein can deteriorate the course of the disease, induce multiple direct COVID-19 symptoms, and contribute to long-term post-covid symptoms. We analyzed the cross reactivity of antibodies to SARS-CoV-2 with own human proteins and showed that antibodies to the nucleocapsid protein can bind to human proteins. In accordance with the possibility of HLA presentation, the main possible targets of the autoantibodies were identified. People with HLA alleles A01:01; A26:01; B39:01; B15:01 are most susceptible to the development of autoimmune processes after COVID-19. |*COVID-19/complications[MESH] |*SARS-CoV-2[MESH] |Antibodies, Viral[MESH] |Humans[MESH] |Nucleoproteins[MESH] |Post-Acute COVID-19 Syndrome[MESH]Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein (epmc).pdf DeepDyve Pubget Overpricing