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10.1093/cei/uxac060

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35732270!9384298!35732270
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suck abstract from ncbi


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pmid35732270      Clin+Exp+Immunol 2022 ; 209 (3): 305-310
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  • Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans #MMPMID35732270
  • Piaggi S; Lorenzini E; Pratesi F; Migliorini P; Pompella A; Bruschi F; Corti A
  • Clin Exp Immunol 2022[Sep]; 209 (3): 305-310 PMID35732270show ga
  • Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme involved in the modulation of critical inflammatory pathways as well as in cancer progression. Auto-antibodies against GSTO1-1 were detected in the serum of patients with esophageal squamous cell carcinoma and were proposed as potential biomarkers in the early detection of the disease. Our findings show that anti-GSTO1-1 antibodies can be found in a variety of inflammatory diseases, including autoimmune rheumatoid arthritis, infectious SARS-CoV-2, and trichinellosis. Our findings strongly suggest that anti-GSTO1-1 antibodies may be a marker of tissue damage/inflammation rather than a specific tumor-associated biomarker.
  • |*COVID-19[MESH]
  • |*Esophageal Neoplasms[MESH]
  • |*Esophageal Squamous Cell Carcinoma[MESH]
  • |Biomarkers, Tumor[MESH]
  • |Glutathione Transferase[MESH]
  • |Humans[MESH]
  • |Inflammation[MESH]


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