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10.1172/jci.insight.152629 http://scihub22266oqcxt.onion/10.1172/jci.insight.152629 35730564!9309048!35730564     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2022 ; 7 (12): ä Nephropedia Template TP {{tp|p=35730564|t=2022. Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections |pdf=|usr=}}{{35730564}} gab.com Text Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=35730564 #FOAvip Thick, viscous respiratory secretions are a major pathogenic feature of COVID-19, but the composition and physical properties of these secretions are poorly understood. We characterized the composition and rheological properties (i.e., resistance to flow) of respiratory secretions collected from intubated COVID-19 patients. We found the percentages of solids and protein content were greatly elevated in COVID-19 compared with heathy control samples and closely resembled levels seen in cystic fibrosis, a genetic disease known for thick, tenacious respiratory secretions. DNA and hyaluronan (HA) were major components of respiratory secretions in COVID-19 and were likewise abundant in cadaveric lung tissues from these patients. COVID-19 secretions exhibited heterogeneous rheological behaviors, with thicker samples showing increased sensitivity to DNase and hyaluronidase treatment. In histologic sections from these same patients, we observed increased accumulation of HA and the hyaladherin versican but reduced tumor necrosis factor-stimulated gene-6 staining, consistent with the inflammatory nature of these secretions. Finally, we observed diminished type I interferon and enhanced inflammatory cytokines in these secretions. Overall, our studies indicated that increases in HA and DNA in COVID-19 respiratory secretion samples correlated with enhanced inflammatory burden and suggested that DNA and HA may be viable therapeutic targets in COVID-19 infection. Twit Text FOAVip Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=35730564 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35730564 #FOAvip English Wikipedia <ref>{{Cite pmid|35730564}}</ref> Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections #MMPMID35730564 Kratochvil MJ; Kaber G; Demirdjian S; Cai PC; Burgener EB; Nagy N; Barlow GL; Popescu M; Nicolls MR; Ozawa MG; Regula DP; Pacheco-Navarro AE; Yang S; de Jesus Perez VA; Karmouty-Quintana H; Peters AM; Zhao B; Buja ML; Johnson PY; Vernon RB; Wight TN; Milla CE; Rogers AJ; Spakowitz AJ; Heilshorn SC; Bollyky PL JCI Insight 2022[Jun]; 7 (12): ä PMID35730564show ga Thick, viscous respiratory secretions are a major pathogenic feature of COVID-19, but the composition and physical properties of these secretions are poorly understood. We characterized the composition and rheological properties (i.e., resistance to flow) of respiratory secretions collected from intubated COVID-19 patients. We found the percentages of solids and protein content were greatly elevated in COVID-19 compared with heathy control samples and closely resembled levels seen in cystic fibrosis, a genetic disease known for thick, tenacious respiratory secretions. DNA and hyaluronan (HA) were major components of respiratory secretions in COVID-19 and were likewise abundant in cadaveric lung tissues from these patients. COVID-19 secretions exhibited heterogeneous rheological behaviors, with thicker samples showing increased sensitivity to DNase and hyaluronidase treatment. In histologic sections from these same patients, we observed increased accumulation of HA and the hyaladherin versican but reduced tumor necrosis factor-stimulated gene-6 staining, consistent with the inflammatory nature of these secretions. Finally, we observed diminished type I interferon and enhanced inflammatory cytokines in these secretions. Overall, our studies indicated that increases in HA and DNA in COVID-19 respiratory secretion samples correlated with enhanced inflammatory burden and suggested that DNA and HA may be viable therapeutic targets in COVID-19 infection. |*COVID-19[MESH] |*Interferon Type I[MESH] |Humans[MESH] |Lung[MESH] |SARS-CoV-2[MESH]Biochemical, biophysical, and immunological characterization of respir(epmc).pdf DeepDyve Pubget Overpricing