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10.1038/s41598-022-13825-7 http://scihub22266oqcxt.onion/10.1038/s41598-022-13825-7 35729319!9212205!35729319     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2022 ; 12 (1): 10484 Nephropedia Template TP {{tp|p=35729319|t=2022. High generation of reactive oxygen species from neutrophils in patients with severe COVID-19 |pdf=|usr=}}{{35729319}} gab.com Text High generation of reactive oxygen species from neutrophils in patients with severe COVID-19 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=35729319 #FOAvip Neutrophilia and an elevated neutrophil:lymphocyte ratio are both characteristic features of severe COVID-19 infection. However, functional neutrophil responses have been poorly investigated in this setting. We utilised a novel PMA-based stimulation assay to determine neutrophil-derived reactive oxygen species (ROS) generation in patients with severe COVID-19 infection, non-COVID related sepsis and healthy study participants. ROS production was markedly elevated in COVID-19 patients with median values ninefold higher than in healthy controls and was particularly high in patients on mechanical ventilation. ROS generation correlated strongly with neutrophil count and elevated levels were also seen in patients with non-COVID related sepsis. Relative values, adjusted for neutrophil count, were high in both groups but extreme low or high values were seen in two patients who died shortly after testing, potentially indicating a predictive value for neutrophil function. Our results show that the high levels of neutrophils observed in patients with COVID-19 and sepsis exhibit functional capacity for ROS generation. This may contribute to the clinical features of acute disease and represents a potential novel target for therapeutic intervention. Twit Text FOAVip High generation of reactive oxygen species from neutrophils in patients with severe COVID-19 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=35729319 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35729319 #FOAvip English Wikipedia <ref>{{Cite pmid|35729319}}</ref> High generation of reactive oxygen species from neutrophils in patients with severe COVID-19 #MMPMID35729319 Veenith T; Martin H; Le Breuilly M; Whitehouse T; Gao-Smith F; Duggal N; Lord JM; Mian R; Sarphie D; Moss P Sci Rep 2022[Jun]; 12 (1): 10484 PMID35729319show ga Neutrophilia and an elevated neutrophil:lymphocyte ratio are both characteristic features of severe COVID-19 infection. However, functional neutrophil responses have been poorly investigated in this setting. We utilised a novel PMA-based stimulation assay to determine neutrophil-derived reactive oxygen species (ROS) generation in patients with severe COVID-19 infection, non-COVID related sepsis and healthy study participants. ROS production was markedly elevated in COVID-19 patients with median values ninefold higher than in healthy controls and was particularly high in patients on mechanical ventilation. ROS generation correlated strongly with neutrophil count and elevated levels were also seen in patients with non-COVID related sepsis. Relative values, adjusted for neutrophil count, were high in both groups but extreme low or high values were seen in two patients who died shortly after testing, potentially indicating a predictive value for neutrophil function. Our results show that the high levels of neutrophils observed in patients with COVID-19 and sepsis exhibit functional capacity for ROS generation. This may contribute to the clinical features of acute disease and represents a potential novel target for therapeutic intervention. |*COVID-19[MESH] |*Sepsis[MESH] |Humans[MESH] |Leukocyte Count[MESH] |Neutrophils[MESH]High generation of reactive oxygen species from neutrophils in patient(epmc).pdf DeepDyve Pubget Overpricing