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10.1146/annurev-biochem-052521-115653 http://scihub22266oqcxt.onion/10.1146/annurev-biochem-052521-115653 35729072!?!35729072 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35729072&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Annu+Rev+Biochem 2022 ; 91 (?): 381-401 Nephropedia Template TP {{tp|p=35729072|t=2022. The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function |pdf=|usr=}}{{35729072}} gab.com Text The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function JO: Annu Rev Biochem http://www.kidney.de/pget.php?&tw=1&pmid=35729072 #FOAvip The persistence of the coronavirus disease 2019 (COVID-19) pandemic has resulted in increasingly disruptive impacts, and it has become the most devastating challenge to global health in a century. The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants challenges the currently available therapeutics for clinical application. Nonstructural proteins (also known as replicase proteins) with versatile biological functions play central roles in viral replication and transcription inside the host cells, and they are the most conserved target proteins among the SARS-CoV-2 variants. Specifically, they constitute the replication-transcription complexes (RTCs) dominating the synthesis of viral RNA. Knowledge of themolecular mechanisms of nonstructural proteins and their assembly into RTCs will benefit the development of antivirals targeting them against existing or potentially emerging variants. In this review, we summarize current knowledge of the structures and functions of coronavirus nonstructural proteins as well as the assembly and functions of RTCs in the life cycle of the virus. Twit Text FOAVip The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function ????Annu Rev Biochem http://www.kidney.de/pget.php?&tw=1&pmid=35729072 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35729072 #FOAvip English Wikipedia <ref>{{Cite pmid|35729072}}</ref> The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function #MMPMID35729072 Lou Z; Rao Z Annu Rev Biochem 2022[Jun]; 91 (?): 381-401 PMID35729072show ga The persistence of the coronavirus disease 2019 (COVID-19) pandemic has resulted in increasingly disruptive impacts, and it has become the most devastating challenge to global health in a century. The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants challenges the currently available therapeutics for clinical application. Nonstructural proteins (also known as replicase proteins) with versatile biological functions play central roles in viral replication and transcription inside the host cells, and they are the most conserved target proteins among the SARS-CoV-2 variants. Specifically, they constitute the replication-transcription complexes (RTCs) dominating the synthesis of viral RNA. Knowledge of themolecular mechanisms of nonstructural proteins and their assembly into RTCs will benefit the development of antivirals targeting them against existing or potentially emerging variants. In this review, we summarize current knowledge of the structures and functions of coronavirus nonstructural proteins as well as the assembly and functions of RTCs in the life cycle of the virus. |*COVID-19 Drug Treatment[MESH] |*SARS-CoV-2[MESH] |Humans[MESH] |RNA, Viral/genetics[MESH]The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex(epmc).pdf DeepDyve Pubget Overpricing