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10.1038/s41591-022-01882-4

http://scihub22266oqcxt.onion/10.1038/s41591-022-01882-4
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35725921!9307477!35725921
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suck abstract from ncbi


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pmid35725921      Nat+Med 2022 ; 28 (7): 1501-1508
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  • Drivers of adaptive evolution during chronic SARS-CoV-2 infections #MMPMID35725921
  • Harari S; Tahor M; Rutsinsky N; Meijer S; Miller D; Henig O; Halutz O; Levytskyi K; Ben-Ami R; Adler A; Paran Y; Stern A
  • Nat Med 2022[Jul]; 28 (7): 1501-1508 PMID35725921show ga
  • In some immunocompromised patients with chronic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, considerable adaptive evolution occurs. Some substitutions found in chronic infections are lineage-defining mutations in variants of concern (VOCs), which has led to the hypothesis that VOCs emerged from chronic infections. In this study, we searched for drivers of VOC-like emergence by consolidating sequencing results from a set of 27 chronic infections. Most substitutions in this set reflected lineage-defining VOC mutations; however, a subset of mutations associated with successful global transmission was absent from chronic infections. We further tested the ability to associate antibody evasion mutations with patient-specific and virus-specific features and found that viral rebound is strongly correlated with the emergence of antibody evasion. We found evidence for dynamic polymorphic viral populations in most patients, suggesting that a compromised immune system selects for antibody evasion in particular niches in a patient's body. We suggest that a tradeoff exists between antibody evasion and transmissibility and that extensive monitoring of chronic infections is necessary to further understanding of VOC emergence.
  • |*COVID-19[MESH]
  • |*Graft vs Host Disease[MESH]
  • |Humans[MESH]
  • |Mutation/genetics[MESH]


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