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10.3389/fimmu.2022.886611 http://scihub22266oqcxt.onion/10.3389/fimmu.2022.886611 35711419!9196734!35711419     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35711419&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2022 ; 13 (ä): 886611 Nephropedia Template TP {{tp|p=35711419|t=2022. Priming With Rhinovirus Protects Mice Against a Lethal Pulmonary Coronavirus Infection |pdf=|usr=}}{{35711419}} gab.com Text Priming With Rhinovirus Protects Mice Against a Lethal Pulmonary Coronavirus Infection JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35711419 #FOAvip Rhinoviruses (RV) have been shown to inhibit subsequent infection by heterologous respiratory viruses, including influenza viruses and severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). To better understand the mechanisms whereby RV protects against pulmonary coronavirus infection, we used a native murine virus, mouse hepatitis virus strain 1 (MHV-1), that causes severe disease in the lungs of infected mice. We found that priming of the respiratory tract with RV completely prevented mortality and reduced morbidity of a lethal MHV-1 infection. Replication of MHV-1 was reduced in RV-primed mouse lungs although expression of antiviral type I interferon, IFN-beta, was more robust in mice infected with MHV-1 alone. We further showed that signaling through the type I interferon receptor was required for survival of mice given a non-lethal dose of MHV-1. RV-primed mice had reduced pulmonary inflammation and hemorrhage and influx of leukocytes, especially neutrophils, in the airways upon MHV-1 infection. Although MHV-1 replication was reduced in RV-primed mice, RV did not inhibit MHV-1 replication in coinfected lung epithelial cells in vitro. In summary, RV-mediated priming in the respiratory tract reduces viral replication, inflammation, and tissue damage, and prevents mortality of a pulmonary coronavirus infection in mice. These results contribute to our understanding of how distinct respiratory viruses interact with the host to affect disease pathogenesis, which is a critical step in understanding how respiratory viral coinfections impact human health. Twit Text FOAVip Priming With Rhinovirus Protects Mice Against a Lethal Pulmonary Coronavirus Infection ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35711419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35711419 #FOAvip English Wikipedia <ref>{{Cite pmid|35711419}}</ref> Priming With Rhinovirus Protects Mice Against a Lethal Pulmonary Coronavirus Infection #MMPMID35711419 Cox G; Gonzalez AJ; Ijezie EC; Rodriguez A; Miller CR; Van Leuven JT; Miura TA Front Immunol 2022[]; 13 (ä): 886611 PMID35711419show ga Rhinoviruses (RV) have been shown to inhibit subsequent infection by heterologous respiratory viruses, including influenza viruses and severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). To better understand the mechanisms whereby RV protects against pulmonary coronavirus infection, we used a native murine virus, mouse hepatitis virus strain 1 (MHV-1), that causes severe disease in the lungs of infected mice. We found that priming of the respiratory tract with RV completely prevented mortality and reduced morbidity of a lethal MHV-1 infection. Replication of MHV-1 was reduced in RV-primed mouse lungs although expression of antiviral type I interferon, IFN-beta, was more robust in mice infected with MHV-1 alone. We further showed that signaling through the type I interferon receptor was required for survival of mice given a non-lethal dose of MHV-1. RV-primed mice had reduced pulmonary inflammation and hemorrhage and influx of leukocytes, especially neutrophils, in the airways upon MHV-1 infection. Although MHV-1 replication was reduced in RV-primed mice, RV did not inhibit MHV-1 replication in coinfected lung epithelial cells in vitro. In summary, RV-mediated priming in the respiratory tract reduces viral replication, inflammation, and tissue damage, and prevents mortality of a pulmonary coronavirus infection in mice. These results contribute to our understanding of how distinct respiratory viruses interact with the host to affect disease pathogenesis, which is a critical step in understanding how respiratory viral coinfections impact human health. |*COVID-19[MESH] |*Coinfection[MESH] |*Enterovirus Infections[MESH] |*Murine hepatitis virus[MESH] |*Pneumonia[MESH] |Animals[MESH] |Lung[MESH] |Mice[MESH] |Rhinovirus[MESH]Priming With Rhinovirus Protects Mice Against a Lethal Pulmonary Coron(epmc).pdf DeepDyve Pubget Overpricing