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10.1007/s00018-022-04318-x http://scihub22266oqcxt.onion/10.1007/s00018-022-04318-x 35708858!9201269!35708858     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2022 ; 79 (7): 365 Nephropedia Template TP {{tp|p=35708858|t=2022. Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19 |pdf=|usr=}}{{35708858}} gab.com Text Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19 JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=35708858 #FOAvip SARS-CoV-2, although not being a circulatory virus, spread from the respiratory tract resulting in multiorgan failures and thrombotic complications, the hallmarks of fatal COVID-19. A convergent contributor could be platelets that beyond hemostatic functions can carry infectious viruses. Here, we profiled 52 patients with severe COVID-19 and demonstrated that circulating platelets of 19 out 20 non-survivor patients contain SARS-CoV-2 in robust correlation with fatal outcome. Platelets containing SARS-CoV-2 might originate from bone marrow and lung megakaryocytes (MKs), the platelet precursors, which were found infected by SARS-CoV-2 in COVID-19 autopsies. Accordingly, MKs undergoing shortened differentiation and expressing anti-viral IFITM1 and IFITM3 RNA as a sign of viral sensing were enriched in the circulation of deadly COVID-19. Infected MKs reach the lung concomitant with a specific MK-related cytokine storm rich in VEGF, PDGF and inflammatory molecules, anticipating fatal outcome. Lung macrophages capture SARS-CoV-2-containing platelets in vivo. The virus contained by platelets is infectious as capture of platelets carrying SARS-CoV-2 propagates infection to macrophages in vitro, in a process blocked by an anti-GPIIbIIIa drug. Altogether, platelets containing infectious SARS-CoV-2 alter COVID-19 pathogenesis and provide a powerful fatality marker. Clinical targeting of platelets might prevent viral spread, thrombus formation and exacerbated inflammation at once and increase survival in COVID-19. Twit Text FOAVip Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19 ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=35708858 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35708858 #FOAvip English Wikipedia <ref>{{Cite pmid|35708858}}</ref> Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19 #MMPMID35708858 Zhu A; Real F; Capron C; Rosenberg AR; Silvin A; Dunsmore G; Zhu J; Cottoignies-Callamarte A; Masse JM; Moine P; Bessis S; Godement M; Geri G; Chiche JD; Valdebenito S; Belouzard S; Dubuisson J; Lorin de la Grandmaison G; Chevret S; Ginhoux F; Eugenin EA; Annane D; Borde EC; Bomsel M Cell Mol Life Sci 2022[Jun]; 79 (7): 365 PMID35708858show ga SARS-CoV-2, although not being a circulatory virus, spread from the respiratory tract resulting in multiorgan failures and thrombotic complications, the hallmarks of fatal COVID-19. A convergent contributor could be platelets that beyond hemostatic functions can carry infectious viruses. Here, we profiled 52 patients with severe COVID-19 and demonstrated that circulating platelets of 19 out 20 non-survivor patients contain SARS-CoV-2 in robust correlation with fatal outcome. Platelets containing SARS-CoV-2 might originate from bone marrow and lung megakaryocytes (MKs), the platelet precursors, which were found infected by SARS-CoV-2 in COVID-19 autopsies. Accordingly, MKs undergoing shortened differentiation and expressing anti-viral IFITM1 and IFITM3 RNA as a sign of viral sensing were enriched in the circulation of deadly COVID-19. Infected MKs reach the lung concomitant with a specific MK-related cytokine storm rich in VEGF, PDGF and inflammatory molecules, anticipating fatal outcome. Lung macrophages capture SARS-CoV-2-containing platelets in vivo. The virus contained by platelets is infectious as capture of platelets carrying SARS-CoV-2 propagates infection to macrophages in vitro, in a process blocked by an anti-GPIIbIIIa drug. Altogether, platelets containing infectious SARS-CoV-2 alter COVID-19 pathogenesis and provide a powerful fatality marker. Clinical targeting of platelets might prevent viral spread, thrombus formation and exacerbated inflammation at once and increase survival in COVID-19. |*COVID-19[MESH] |*Thrombosis[MESH] |Blood Platelets[MESH] |Humans[MESH] |Lung[MESH] |Megakaryocytes[MESH] |Membrane Proteins[MESH] |RNA-Binding Proteins[MESH]Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipat(epmc).pdf DeepDyve Pubget Overpricing