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10.1126/scitranslmed.abo0686 http://scihub22266oqcxt.onion/10.1126/scitranslmed.abo0686 35704599!9972878!35704599     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Transl+Med 2022 ; 14 (649): eabo0686 Nephropedia Template TP {{tp|p=35704599|t=2022. Granzyme K(+) CD8 T cells form a core population in inflamed human tissue |pdf=|usr=}}{{35704599}} gab.com Text Granzyme K(+) CD8 T cells form a core population in inflamed human tissue JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=35704599 #FOAvip T cell-derived pro-inflammatory cytokines are a major driver of rheumatoid arthritis (RA) pathogenesis. Although these cytokines have traditionally been attributed to CD4 T cells, we have found that CD8 T cells are notably abundant in synovium and make more interferon (IFN)-gamma and nearly as much tumor necrosis factor (TNF) as their CD4 T cell counterparts. Furthermore, using unbiased high-dimensional single-cell RNA-seq and flow cytometric data, we found that the vast majority of synovial tissue and synovial fluid CD8 T cells belong to an effector CD8 T cell population characterized by high expression of granzyme K (GzmK) and low expression of granzyme B (GzmB) and perforin. Functional experiments demonstrate that these GzmK(+) GzmB(+) CD8 T cells are major cytokine producers with low cytotoxic potential. Using T cell receptor repertoire data, we found that CD8 GzmK(+) GzmB(+) T cells are clonally expanded in synovial tissues and maintain their granzyme expression and overall cell state in blood, suggesting that they are enriched in tissue but also circulate. Using GzmK and GzmB signatures, we found that GzmK-expressing CD8 T cells were also the major CD8 T cell population in the gut, kidney, and coronavirus disease 2019 (COVID-19) bronchoalveolar lavage fluid, suggesting that they form a core population of tissue-associated T cells across diseases and human tissues. We term this population tissue-enriched expressing GzmK or T(teK) CD8 cells. Armed to produce cytokines in response to both antigen-dependent and antigen-independent stimuli, CD8 T(teK) cells have the potential to drive inflammation. Twit Text FOAVip Granzyme K(+) CD8 T cells form a core population in inflamed human tissue ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=35704599 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35704599 #FOAvip English Wikipedia <ref>{{Cite pmid|35704599}}</ref> Granzyme K(+) CD8 T cells form a core population in inflamed human tissue #MMPMID35704599 Jonsson AH; Zhang F; Dunlap G; Gomez-Rivas E; Watts GFM; Faust HJ; Rupani KV; Mears JR; Meednu N; Wang R; Keras G; Coblyn JS; Massarotti EM; Todd DJ; Anolik JH; McDavid A; Wei K; Rao DA; Raychaudhuri S; Brenner MB Sci Transl Med 2022[Jun]; 14 (649): eabo0686 PMID35704599show ga T cell-derived pro-inflammatory cytokines are a major driver of rheumatoid arthritis (RA) pathogenesis. Although these cytokines have traditionally been attributed to CD4 T cells, we have found that CD8 T cells are notably abundant in synovium and make more interferon (IFN)-gamma and nearly as much tumor necrosis factor (TNF) as their CD4 T cell counterparts. Furthermore, using unbiased high-dimensional single-cell RNA-seq and flow cytometric data, we found that the vast majority of synovial tissue and synovial fluid CD8 T cells belong to an effector CD8 T cell population characterized by high expression of granzyme K (GzmK) and low expression of granzyme B (GzmB) and perforin. Functional experiments demonstrate that these GzmK(+) GzmB(+) CD8 T cells are major cytokine producers with low cytotoxic potential. Using T cell receptor repertoire data, we found that CD8 GzmK(+) GzmB(+) T cells are clonally expanded in synovial tissues and maintain their granzyme expression and overall cell state in blood, suggesting that they are enriched in tissue but also circulate. Using GzmK and GzmB signatures, we found that GzmK-expressing CD8 T cells were also the major CD8 T cell population in the gut, kidney, and coronavirus disease 2019 (COVID-19) bronchoalveolar lavage fluid, suggesting that they form a core population of tissue-associated T cells across diseases and human tissues. We term this population tissue-enriched expressing GzmK or T(teK) CD8 cells. Armed to produce cytokines in response to both antigen-dependent and antigen-independent stimuli, CD8 T(teK) cells have the potential to drive inflammation. |*COVID-19[MESH] |CD4-Positive T-Lymphocytes/metabolism[MESH] |CD8-Positive T-Lymphocytes/metabolism[MESH] |Cytokines/metabolism[MESH] |Granzymes/metabolism[MESH]Granzyme K(+) CD8 T cells form a core population in inflamed human tis(epmc).pdf DeepDyve Pubget Overpricing