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10.1371/journal.ppat.1010590 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1010590 35700214!9197039!35700214     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2022 ; 18 (6): e1010590 Nephropedia Template TP {{tp|p=35700214|t=2022. Significant role of host sialylated glycans in the infection and spread of severe acute respiratory syndrome coronavirus 2 |pdf=|usr=}}{{35700214}} gab.com Text Significant role of host sialylated glycans in the infection and spread of severe acute respiratory syndrome coronavirus 2 JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=35700214 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been transmitted across all over the world, in contrast to the limited epidemic of genetically- and virologically-related SARS-CoV. However, the molecular basis explaining the difference in the virological characteristics among SARS-CoV-2 and SARS-CoV has been poorly defined. Here we identified that host sialoglycans play a significant role in the efficient spread of SARS-CoV-2 infection, while this was not the case with SARS-CoV. SARS-CoV-2 infection was significantly inhibited by alpha2-6-linked sialic acid-containing compounds, but not by alpha2-3 analog, in VeroE6/TMPRSS2 cells. The alpha2-6-linked compound bound to SARS-CoV-2 spike S1 subunit to competitively inhibit SARS-CoV-2 attachment to cells. Enzymatic removal of cell surface sialic acids impaired the interaction between SARS-CoV-2 spike and angiotensin-converting enzyme 2 (ACE2), and suppressed the efficient spread of SARS-CoV-2 infection over time, in contrast to its least effect on SARS-CoV spread. Our study provides a novel molecular basis of SARS-CoV-2 infection which illustrates the distinctive characteristics from SARS-CoV. Twit Text FOAVip Significant role of host sialylated glycans in the infection and spread of severe acute respiratory syndrome coronavirus 2 ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=35700214 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35700214 #FOAvip English Wikipedia <ref>{{Cite pmid|35700214}}</ref> Significant role of host sialylated glycans in the infection and spread of severe acute respiratory syndrome coronavirus 2 #MMPMID35700214 Saso W; Yamasaki M; Nakakita SI; Fukushi S; Tsuchimoto K; Watanabe N; Sriwilaijaroen N; Kanie O; Muramatsu M; Takahashi Y; Matano T; Takeda M; Suzuki Y; Watashi K PLoS Pathog 2022[Jun]; 18 (6): e1010590 PMID35700214show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been transmitted across all over the world, in contrast to the limited epidemic of genetically- and virologically-related SARS-CoV. However, the molecular basis explaining the difference in the virological characteristics among SARS-CoV-2 and SARS-CoV has been poorly defined. Here we identified that host sialoglycans play a significant role in the efficient spread of SARS-CoV-2 infection, while this was not the case with SARS-CoV. SARS-CoV-2 infection was significantly inhibited by alpha2-6-linked sialic acid-containing compounds, but not by alpha2-3 analog, in VeroE6/TMPRSS2 cells. The alpha2-6-linked compound bound to SARS-CoV-2 spike S1 subunit to competitively inhibit SARS-CoV-2 attachment to cells. Enzymatic removal of cell surface sialic acids impaired the interaction between SARS-CoV-2 spike and angiotensin-converting enzyme 2 (ACE2), and suppressed the efficient spread of SARS-CoV-2 infection over time, in contrast to its least effect on SARS-CoV spread. Our study provides a novel molecular basis of SARS-CoV-2 infection which illustrates the distinctive characteristics from SARS-CoV. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Humans[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Polysaccharides/metabolism[MESH] |Protein Binding[MESH]Significant role of host sialylated glycans in the infection and sprea(epmc).pdf DeepDyve Pubget Overpricing