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10.3390/jcm11113099

http://scihub22266oqcxt.onion/10.3390/jcm11113099
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35683485!9180990!35683485
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suck abstract from ncbi


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pmid35683485      J+Clin+Med 2022 ; 11 (11): ä
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  • The Role of Heparin in COVID-19: An Update after Two Years of Pandemics #MMPMID35683485
  • Mangiafico M; Caff A; Costanzo L
  • J Clin Med 2022[May]; 11 (11): ä PMID35683485show ga
  • Coronavirus disease 2019 (COVID-19) is associated with an increased risk of venous thromboembolism (VTE) and coagulopathy, especially in critically ill patients. Endothelial damage induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is emerging as a crucial pathogenetic mechanism for the development of complications in an acute phase of the illness and for several postdischarge sequalae. Heparin has been shown to have a positive impact on COVID-19 due to its anticoagulant function. Moreover, several other biological actions of heparin were postulated: a potential anti-inflammatory and antiviral effect through the main protease (M(pro)) and heparansulfate (HS) binding and a protection from the damage of vascular endothelial cells. In this paper, we reviewed available evidence on heparin treatment in COVID-19 acute illness and chronic sequalae, focusing on the difference between prophylactic and therapeutic dosage.
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