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10.1038/s41467-022-30959-4 http://scihub22266oqcxt.onion/10.1038/s41467-022-30959-4 35680919!9184625!35680919     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35680919&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Nat+Commun 2022 ; 13 (1): 3230 Nephropedia Template TP {{tp|p=35680919|t=2022. Efferocytosis requires periphagosomal Ca(2+)-signaling and TRPM7-mediated electrical activity |pdf=|usr=}}{{35680919}} gab.com Text Efferocytosis requires periphagosomal Ca(2+)-signaling and TRPM7-mediated electrical activity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35680919 #FOAvip Efficient clearance of apoptotic cells by phagocytosis, also known as efferocytosis, is fundamental to developmental biology, organ physiology, and immunology. Macrophages use multiple mechanisms to detect and engulf apoptotic cells, but the signaling pathways that regulate the digestion of the apoptotic cell cargo, such as the dynamic Ca(2+) signals, are poorly understood. Using an siRNA screen, we identify TRPM7 as a Ca(2+)-conducting ion channel essential for phagosome maturation during efferocytosis. Trpm7-targeted macrophages fail to fully acidify or digest their phagosomal cargo in the absence of TRPM7. Through perforated patch electrophysiology, we demonstrate that TRPM7 mediates a pH-activated cationic current necessary to sustain phagosomal acidification. Using mice expressing a genetically-encoded Ca(2+) sensor, we observe that phagosome maturation requires peri-phagosomal Ca(2+)-signals dependent on TRPM7. Overall, we reveal TRPM7 as a central regulator of phagosome maturation during macrophage efferocytosis. Twit Text FOAVip Efferocytosis requires periphagosomal Ca(2+)-signaling and TRPM7-mediated electrical activity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35680919 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35680919 #FOAvip English Wikipedia <ref>{{Cite pmid|35680919}}</ref> Efferocytosis requires periphagosomal Ca(2+)-signaling and TRPM7-mediated electrical activity #MMPMID35680919 Schappe MS; Stremska ME; Busey GW; Downs TK; Seegren PV; Mendu SK; Flegal Z; Doyle CA; Stipes EJ; Desai BN Nat Commun 2022[Jun]; 13 (1): 3230 PMID35680919show ga Efficient clearance of apoptotic cells by phagocytosis, also known as efferocytosis, is fundamental to developmental biology, organ physiology, and immunology. Macrophages use multiple mechanisms to detect and engulf apoptotic cells, but the signaling pathways that regulate the digestion of the apoptotic cell cargo, such as the dynamic Ca(2+) signals, are poorly understood. Using an siRNA screen, we identify TRPM7 as a Ca(2+)-conducting ion channel essential for phagosome maturation during efferocytosis. Trpm7-targeted macrophages fail to fully acidify or digest their phagosomal cargo in the absence of TRPM7. Through perforated patch electrophysiology, we demonstrate that TRPM7 mediates a pH-activated cationic current necessary to sustain phagosomal acidification. Using mice expressing a genetically-encoded Ca(2+) sensor, we observe that phagosome maturation requires peri-phagosomal Ca(2+)-signals dependent on TRPM7. Overall, we reveal TRPM7 as a central regulator of phagosome maturation during macrophage efferocytosis. |*Calcium Signaling[MESH] |*Phagocytosis/physiology[MESH] |*TRPM Cation Channels/genetics/metabolism[MESH] |Animals[MESH] |Macrophages/metabolism[MESH] |Mice[MESH]Efferocytosis requires periphagosomal Ca(2+)-signaling and TRPM7-media(epmc).pdf DeepDyve Pubget Overpricing