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10.1016/j.xcrm.2022.100652 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2022.100652 35675822!9110324!35675822     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35675822&cmd=llinks): Failed to open stream: HTTP request failed! 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Mature neutrophils and a NF-kappaB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19 |pdf=|usr=}}{{35675822}} gab.com Text Mature neutrophils and a NF-kappaB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19 JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=35675822 #FOAvip Disease recovery dynamics are often difficult to assess, as patients display heterogeneous recovery courses. To model recovery dynamics, exemplified by severe COVID-19, we apply a computational scheme on longitudinally sampled blood transcriptomes, generating recovery states, which we then link to cellular and molecular mechanisms, presenting a framework for studying the kinetics of recovery compared with non-recovery over time and long-term effects of the disease. Specifically, a decrease in mature neutrophils is the strongest cellular effect during recovery, with direct implications on disease outcome. Furthermore, we present strong indications for global regulatory changes in gene programs, decoupled from cell compositional changes, including an early rise in T cell activation and differentiation, resulting in immune rebalancing between interferon and NF-kappaB activity and restoration of cell homeostasis. Overall, we present a clinically relevant computational framework for modeling disease recovery, paving the way for future studies of the recovery dynamics in other diseases and tissues. Twit Text FOAVip Mature neutrophils and a NF-kappaB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19 ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=35675822 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35675822 #FOAvip English Wikipedia <ref>{{Cite pmid|35675822}}</ref> Mature neutrophils and a NF-kappaB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19 #MMPMID35675822 Frishberg A; Kooistra E; Nuesch-Germano M; Pecht T; Milman N; Reusch N; Warnat-Herresthal S; Bruse N; Handler K; Theis H; Kraut M; van Rijssen E; van Cranenbroek B; Koenen HJ; Heesakkers H; van den Boogaard M; Zegers M; Pickkers P; Becker M; Aschenbrenner AC; Ulas T; Theis FJ; Shen-Orr SS; Schultze JL; Kox M Cell Rep Med 2022[Jun]; 3 (6): 100652 PMID35675822show ga Disease recovery dynamics are often difficult to assess, as patients display heterogeneous recovery courses. To model recovery dynamics, exemplified by severe COVID-19, we apply a computational scheme on longitudinally sampled blood transcriptomes, generating recovery states, which we then link to cellular and molecular mechanisms, presenting a framework for studying the kinetics of recovery compared with non-recovery over time and long-term effects of the disease. Specifically, a decrease in mature neutrophils is the strongest cellular effect during recovery, with direct implications on disease outcome. Furthermore, we present strong indications for global regulatory changes in gene programs, decoupled from cell compositional changes, including an early rise in T cell activation and differentiation, resulting in immune rebalancing between interferon and NF-kappaB activity and restoration of cell homeostasis. Overall, we present a clinically relevant computational framework for modeling disease recovery, paving the way for future studies of the recovery dynamics in other diseases and tissues. |*COVID-19[MESH] |*NF-kappa B/genetics[MESH] |Cell Differentiation[MESH] |Humans[MESH] |Interferons/metabolism[MESH] |Neutrophils/metabolism[MESH]Mature neutrophils and a NF-kappaB-to-IFN transition determine the uni(epmc).pdf DeepDyve Pubget Overpricing