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10.1016/j.celrep.2022.110952

http://scihub22266oqcxt.onion/10.1016/j.celrep.2022.110952
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suck abstract from ncbi


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pmid35675811      Cell+Rep 2022 ; 39 (11): 110952
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  • Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles #MMPMID35675811
  • Becerra-Artiles A; Calvo-Calle JM; Co MD; Nanaware PP; Cruz J; Weaver GC; Lu L; Forconi C; Finberg RW; Moormann AM; Stern LJ
  • Cell Rep 2022[Jun]; 39 (11): 110952 PMID35675811show ga
  • Sequence homology between SARS-CoV-2 and common-cold human coronaviruses (HCoVs) raises the possibility that memory responses to prior HCoV infection can affect T cell response in COVID-19. We studied T cell responses to SARS-CoV-2 and HCoVs in convalescent COVID-19 donors and identified a highly conserved SARS-CoV-2 sequence, S(811-831), with overlapping epitopes presented by common MHC class II proteins HLA-DQ5 and HLA-DP4. These epitopes are recognized by low-abundance CD4 T cells from convalescent COVID-19 donors, mRNA vaccine recipients, and uninfected donors. TCR sequencing revealed a diverse repertoire with public TCRs. T cell cross-reactivity is driven by the high conservation across human and animal coronaviruses of T cell contact residues in both HLA-DQ5 and HLA-DP4 binding frames, with distinct patterns of HCoV cross-reactivity explained by MHC class II binding preferences and substitutions at secondary TCR contact sites. These data highlight S(811-831) as a highly conserved CD4 T cell epitope broadly recognized across human populations.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |Alleles[MESH]
  • |CD4-Positive T-Lymphocytes[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Epitopes, T-Lymphocyte[MESH]
  • |HLA Antigens[MESH]
  • |Humans[MESH]
  • |Receptors, Antigen, T-Cell[MESH]


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